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Cross-neutralization of four paramyxoviruses by a human monoclonal antibody

Author

Listed:
  • Davide Corti

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland
    Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Siro Bianchi

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Fabrizia Vanzetta

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Andrea Minola

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Laurent Perez

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Gloria Agatic

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Barbara Guarino

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Chiara Silacci

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Jessica Marcandalli

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Benjamin J. Marsland

    (University of Lausanne, Service de Pneumologie, CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland)

  • Antonio Piralla

    (Policlinico San Matteo, IRCCS, Piazzale Camillo Golgi 1, 27100 Pavia, Italy)

  • Elena Percivalle

    (Policlinico San Matteo, IRCCS, Piazzale Camillo Golgi 1, 27100 Pavia, Italy)

  • Federica Sallusto

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Fausto Baldanti

    (Policlinico San Matteo, IRCCS, Piazzale Camillo Golgi 1, 27100 Pavia, Italy)

  • Antonio Lanzavecchia

    (Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Institute of Microbiology, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland)

Abstract

A human monoclonal antibody has been identified which can cross-neutralize both human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), demonstrating that a single monoclonal antibody can target different viruses, a discovery that may lead to the creation of new therapeutics and vaccines.

Suggested Citation

  • Davide Corti & Siro Bianchi & Fabrizia Vanzetta & Andrea Minola & Laurent Perez & Gloria Agatic & Barbara Guarino & Chiara Silacci & Jessica Marcandalli & Benjamin J. Marsland & Antonio Piralla & Elen, 2013. "Cross-neutralization of four paramyxoviruses by a human monoclonal antibody," Nature, Nature, vol. 501(7467), pages 439-443, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12442
    DOI: 10.1038/nature12442
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    Citations

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    Cited by:

    1. Karen J. Gonzalez & Jiachen Huang & Miria F. Criado & Avik Banerjee & Stephen M. Tompkins & Jarrod J. Mousa & Eva-Maria Strauch, 2024. "A general computational design strategy for stabilizing viral class I fusion proteins," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Ching-Lin Hsieh & Scott A. Rush & Concepcion Palomo & Chia-Wei Chou & Whitney Pickens & Vicente Más & Jason S. McLellan, 2022. "Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Ariel Isaacs & Yu Shang Low & Kyle L. Macauslane & Joy Seitanidou & Cassandra L. Pegg & Stacey T. M. Cheung & Benjamin Liang & Connor A. P. Scott & Michael J. Landsberg & Benjamin L. Schulz & Keith J., 2023. "Structure and antigenicity of divergent Henipavirus fusion glycoproteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Xiao Xiao & Arthur Fridman & Lu Zhang & Pavlo Pristatsky & Eberhard Durr & Michael Minnier & Aimin Tang & Kara S. Cox & Zhiyun Wen & Renee Moore & Dongrui Tian & Jennifer D. Galli & Scott Cosmi & Mich, 2022. "Profiling of hMPV F-specific antibodies isolated from human memory B cells," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Madelyn Cabán & Justas V. Rodarte & Madeleine Bibby & Matthew D. Gray & Justin J. Taylor & Marie Pancera & Jim Boonyaratanakornkit, 2023. "Cross-protective antibodies against common endemic respiratory viruses," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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