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A type III effector antagonizes death receptor signalling during bacterial gut infection

Author

Listed:
  • Jaclyn S. Pearson

    (University of Melbourne, Victoria 3010, Australia)

  • Cristina Giogha

    (University of Melbourne, Victoria 3010, Australia)

  • Sze Ying Ong

    (University of Melbourne, Victoria 3010, Australia)

  • Catherine L. Kennedy

    (University of Melbourne, Victoria 3010, Australia)

  • Michelle Kelly

    (University of Melbourne, Victoria 3010, Australia)

  • Keith S. Robinson

    (MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK)

  • Tania Wong Fok Lung

    (University of Melbourne, Victoria 3010, Australia)

  • Ashley Mansell

    (Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Victoria 3010, Australia)

  • Patrice Riedmaier

    (University of Melbourne, Victoria 3010, Australia)

  • Clare V. L. Oates

    (University of Melbourne, Victoria 3010, Australia)

  • Ali Zaid

    (University of Melbourne, Victoria 3010, Australia)

  • Sabrina Mühlen

    (University of Melbourne, Victoria 3010, Australia)

  • Valerie F. Crepin

    (MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK)

  • Olivier Marches

    (Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK)

  • Ching-Seng Ang

    (Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia)

  • Nicholas A. Williamson

    (Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia)

  • Lorraine A. O’Reilly

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    University of Melbourne)

  • Aleksandra Bankovacki

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Ueli Nachbur

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Giuseppe Infusini

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Andrew I. Webb

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    University of Melbourne)

  • John Silke

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    University of Melbourne)

  • Andreas Strasser

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    University of Melbourne)

  • Gad Frankel

    (MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK)

  • Elizabeth L. Hartland

    (University of Melbourne, Victoria 3010, Australia
    Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria 3052, Australia)

Abstract

Colonizing enteric bacteria are shown to inhibit the antimicrobial process of host cell apoptosis through the action of NleB1, a type III secretion system effector with N-acetylglucosamine transferase activity, which can bind and modify eukaryotic death-domain-containing proteins.

Suggested Citation

  • Jaclyn S. Pearson & Cristina Giogha & Sze Ying Ong & Catherine L. Kennedy & Michelle Kelly & Keith S. Robinson & Tania Wong Fok Lung & Ashley Mansell & Patrice Riedmaier & Clare V. L. Oates & Ali Zaid, 2013. "A type III effector antagonizes death receptor signalling during bacterial gut infection," Nature, Nature, vol. 501(7466), pages 247-251, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7466:d:10.1038_nature12524
    DOI: 10.1038/nature12524
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