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Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

Author

Listed:
  • Giovanni D’Angelo

    (Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
    Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Takefumi Uemura

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Chia-Chen Chuang

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Elena Polishchuk

    (Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Michele Santoro

    (Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Henna Ohvo-Rekilä

    (Biochemistry, Åbo Akademi University, Artillerigatan 6 A III, BioCity, FI-20520 Turku, Finland)

  • Takashi Sato

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Giuseppe Di Tullio

    (Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy)

  • Antonio Varriale

    (Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Sabato D’Auria

    (Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Tiziana Daniele

    (Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy)

  • Fabrizio Capuani

    (Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy)

  • Ludger Johannes

    (Institut Curie Centre de Recherche, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS, UMR144, F-75248 Paris, France)

  • Peter Mattjus

    (Biochemistry, Åbo Akademi University, Artillerigatan 6 A III, BioCity, FI-20520 Turku, Finland)

  • Maria Monti

    (Università di Napoli FedericoII, ViaGaetano Salvatore 482, 80145 Napoli, Italy)

  • Piero Pucci

    (Università di Napoli FedericoII, ViaGaetano Salvatore 482, 80145 Napoli, Italy)

  • Roger L. Williams

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • John E. Burke

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Frances M. Platt

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Akihiro Harada

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
    Osaka University, Osaka 565-0871, Japan)

  • Maria Antonietta De Matteis

    (Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy)

Abstract

Glucosylceramide (GlcCer), a common precursor of different glycosphingolipids, is shown to be channelled to two distinct pathways in the Golgi; non-vesicular transport from the cis- to trans-Golgi network results in the synthesis of the globo series of glycosphingolipids, whereas vesicular transport is the main source of GlcCer for ganglioside synthesis in the Golgi cisternae.

Suggested Citation

  • Giovanni D’Angelo & Takefumi Uemura & Chia-Chen Chuang & Elena Polishchuk & Michele Santoro & Henna Ohvo-Rekilä & Takashi Sato & Giuseppe Di Tullio & Antonio Varriale & Sabato D’Auria & Tiziana Daniel, 2013. "Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi," Nature, Nature, vol. 501(7465), pages 116-120, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7465:d:10.1038_nature12423
    DOI: 10.1038/nature12423
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