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Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

Author

Listed:
  • Gregory I. Lang

    (Princeton University
    Present address: Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.)

  • Daniel P. Rice

    (and FAS Center for Systems Biology, Harvard University)

  • Mark J. Hickman

    (Rowan University)

  • Erica Sodergren

    (The Genome Institute, Washington University School of Medicine)

  • George M. Weinstock

    (The Genome Institute, Washington University School of Medicine)

  • David Botstein

    (Princeton University)

  • Michael M. Desai

    (and FAS Center for Systems Biology, Harvard University)

Abstract

Whole-genome whole-population sequencing is used to examine the dynamics of genome-sequence evolution in Saccharomyces cerevisiae populations for 1,000 generations; this reveals patterns of sequence evolution driven by pervasive genetic hitchhiking and interference, and shows that beneficial mutations that escape drift and increase in frequency typically occur in cohorts.

Suggested Citation

  • Gregory I. Lang & Daniel P. Rice & Mark J. Hickman & Erica Sodergren & George M. Weinstock & David Botstein & Michael M. Desai, 2013. "Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations," Nature, Nature, vol. 500(7464), pages 571-574, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12344
    DOI: 10.1038/nature12344
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    Citations

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    Cited by:

    1. Wojtowicz Andrzej J. & Miller Craig R. & Joyce Paul, 2015. "Inference for one-step beneficial mutations using next generation sequencing," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 14(1), pages 65-81, February.
    2. Andreas Wagner, 2023. "Evolvability-enhancing mutations in the fitness landscapes of an RNA and a protein," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Sébastien Boyer & Lucas Hérissant & Gavin Sherlock, 2021. "Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment," PLOS Genetics, Public Library of Science, vol. 17(1), pages 1-27, January.
    4. Andrea Fulgione & Célia Neto & Ahmed F. Elfarargi & Emmanuel Tergemina & Shifa Ansari & Mehmet Göktay & Herculano Dinis & Nina Döring & Pádraic J. Flood & Sofia Rodriguez-Pacheco & Nora Walden & Marcu, 2022. "Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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