IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v500y2013i7464d10.1038_nature12344.html
   My bibliography  Save this article

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

Author

Listed:
  • Gregory I. Lang

    (Princeton University
    Present address: Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.)

  • Daniel P. Rice

    (and FAS Center for Systems Biology, Harvard University)

  • Mark J. Hickman

    (Rowan University)

  • Erica Sodergren

    (The Genome Institute, Washington University School of Medicine)

  • George M. Weinstock

    (The Genome Institute, Washington University School of Medicine)

  • David Botstein

    (Princeton University)

  • Michael M. Desai

    (and FAS Center for Systems Biology, Harvard University)

Abstract

Whole-genome whole-population sequencing is used to examine the dynamics of genome-sequence evolution in Saccharomyces cerevisiae populations for 1,000 generations; this reveals patterns of sequence evolution driven by pervasive genetic hitchhiking and interference, and shows that beneficial mutations that escape drift and increase in frequency typically occur in cohorts.

Suggested Citation

  • Gregory I. Lang & Daniel P. Rice & Mark J. Hickman & Erica Sodergren & George M. Weinstock & David Botstein & Michael M. Desai, 2013. "Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations," Nature, Nature, vol. 500(7464), pages 571-574, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12344
    DOI: 10.1038/nature12344
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12344
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12344?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wojtowicz Andrzej J. & Miller Craig R. & Joyce Paul, 2015. "Inference for one-step beneficial mutations using next generation sequencing," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 14(1), pages 65-81, February.
    2. Andreas Wagner, 2023. "Evolvability-enhancing mutations in the fitness landscapes of an RNA and a protein," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Sébastien Boyer & Lucas Hérissant & Gavin Sherlock, 2021. "Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment," PLOS Genetics, Public Library of Science, vol. 17(1), pages 1-27, January.
    4. Piaopiao Chen & Jianzhi Zhang, 2024. "The loci of environmental adaptation in a model eukaryote," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Andrea Fulgione & Célia Neto & Ahmed F. Elfarargi & Emmanuel Tergemina & Shifa Ansari & Mehmet Göktay & Herculano Dinis & Nina Döring & Pádraic J. Flood & Sofia Rodriguez-Pacheco & Nora Walden & Marcu, 2022. "Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12344. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.