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The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

Author

Listed:
  • Jens Füllgrabe

    (Cancer Centrum Karolinska, Karolinska Institutet, Stockholm 17176, Sweden)

  • Melinda A. Lynch-Day

    (Cellular and Developmental Biology and Biological Chemistry, University of Michigan, Ann Arbor)

  • Nina Heldring

    (Karolinska Institutet, Stockholm 17177, Sweden)

  • Wenbo Li

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Robert B. Struijk

    (Cancer Centrum Karolinska, Karolinska Institutet, Stockholm 17176, Sweden)

  • Qi Ma

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Graduate Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, California 92093, USA)

  • Ola Hermanson

    (Karolinska Institutet, Stockholm 17177, Sweden)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Daniel J. Klionsky

    (Cellular and Developmental Biology and Biological Chemistry, University of Michigan, Ann Arbor)

  • Bertrand Joseph

    (Cancer Centrum Karolinska, Karolinska Institutet, Stockholm 17176, Sweden)

Abstract

Induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation through downregulation of the histone acetyltransferase hMOF, showing that histone modifications regulate the outcome of autophagy.

Suggested Citation

  • Jens Füllgrabe & Melinda A. Lynch-Day & Nina Heldring & Wenbo Li & Robert B. Struijk & Qi Ma & Ola Hermanson & Michael G. Rosenfeld & Daniel J. Klionsky & Bertrand Joseph, 2013. "The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy," Nature, Nature, vol. 500(7463), pages 468-471, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7463:d:10.1038_nature12313
    DOI: 10.1038/nature12313
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    Cited by:

    1. Fei He & Qi Yu & Min Wang & Rongsha Wang & Xuanyunjing Gong & Feng Ge & Xilan Yu & Shanshan Li, 2022. "SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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