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Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

Author

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  • Guangwen Lu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Yawei Hu

    (School of Life Sciences, Anhui University)

  • Qihui Wang

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Jianxun Qi

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Feng Gao

    (Laboratory of Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences
    School of Life Sciences, Sichuan University, Chengdu 610064, Sichuan, China)

  • Yan Li

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Yanfang Zhang

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology)

  • Wei Zhang

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Yuan Yuan

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    School of Life Sciences, University of Science and Technology of China)

  • Jinku Bao

    (School of Life Sciences, Sichuan University, Chengdu 610064, Sichuan, China)

  • Buchang Zhang

    (School of Life Sciences, Anhui University)

  • Yi Shi

    (Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences)

  • Jinghua Yan

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • George F. Gao

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology
    School of Life Sciences, University of Science and Technology of China
    Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences)

Abstract

MERS-CoV is a newly emerged coronavirus that is related to SARS-CoV and has proven fatal in half of the people it has infected to date: here the crystal structure of the MERS-CoV receptor binding domain is presented in complex with its receptor on human cells, CD26.

Suggested Citation

  • Guangwen Lu & Yawei Hu & Qihui Wang & Jianxun Qi & Feng Gao & Yan Li & Yanfang Zhang & Wei Zhang & Yuan Yuan & Jinku Bao & Buchang Zhang & Yi Shi & Jinghua Yan & George F. Gao, 2013. "Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26," Nature, Nature, vol. 500(7461), pages 227-231, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12328
    DOI: 10.1038/nature12328
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    Cited by:

    1. Milad Haghani & Pegah Varamini, 2021. "Temporal evolution, most influential studies and sleeping beauties of the coronavirus literature," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 7005-7050, August.
    2. Tuersunjiang Keyoumu & Wanbiao Ma & Ke Guo, 2023. "Global Stability of a MERS-CoV Infection Model with CTL Immune Response and Intracellular Delay," Mathematics, MDPI, vol. 11(4), pages 1-26, February.
    3. Zhongmou Chao & Ekaterina Selivanovitch & Konstantinos Kallitsis & Zixuan Lu & Ambika Pachaury & Róisín Owens & Susan Daniel, 2024. "Recreating the biological steps of viral infection on a cell-free bioelectronic platform to profile viral variants of concern," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Julian Heuberger & Lichao Liu & Hilmar Berger & Joop Heuvel & Manqiang Lin & Stefanie Müllerke & Safak Bayram & Giulia Beccaceci & Hugo Jonge & Ermanno Gherardi & Michael Sigal, 2025. "Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration," Nature Communications, Nature, vol. 16(1), pages 1-17, December.

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