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Reactivating head regrowth in a regeneration-deficient planarian species

Author

Listed:
  • S.-Y. Liu

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany)

  • C. Selck

    (DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany)

  • B. Friedrich

    (DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany)

  • R. Lutz

    (DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany)

  • M. Vila-Farré

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany)

  • A. Dahl

    (Deep Sequencing Group-SFB655, DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Biotechnology Center (Biotec), Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany)

  • H. Brandl

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany)

  • N. Lakshmanaperumal

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany)

  • I. Henry

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany)

  • J. C. Rink

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
    DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany)

Abstract

Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; here knocking down components of the Wnt signalling pathway rescues head regeneration in the regeneration-impaired planarian Dendrocoelum lacteum, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

Suggested Citation

  • S.-Y. Liu & C. Selck & B. Friedrich & R. Lutz & M. Vila-Farré & A. Dahl & H. Brandl & N. Lakshmanaperumal & I. Henry & J. C. Rink, 2013. "Reactivating head regrowth in a regeneration-deficient planarian species," Nature, Nature, vol. 500(7460), pages 81-84, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12414
    DOI: 10.1038/nature12414
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