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The molecular logic for planarian regeneration along the anterior–posterior axis

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  • Yoshihiko Umesono

    (RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
    Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
    Present address: Department of Life Systems, Institute of Technology and Science, University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, Japan.)

  • Junichi Tasaki

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Yui Nishimura

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Martina Hrouda

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Eri Kawaguchi

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Shigenobu Yazawa

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Osamu Nishimura

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Kazutaka Hosoda

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Takeshi Inoue

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

  • Kiyokazu Agata

    (Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan)

Abstract

More than a century ago, Thomas Hunt Morgan attempted to explain the extraordinary regenerative ability of planarians such as Dugesia japonica, which can regenerate a complete individual even from a tail fragment, by proposing that two opposing morphogenetic gradients along the anterior–posterior axis are required for regeneration; here ERK and β-catenin signalling are shown to form these gradients.

Suggested Citation

  • Yoshihiko Umesono & Junichi Tasaki & Yui Nishimura & Martina Hrouda & Eri Kawaguchi & Shigenobu Yazawa & Osamu Nishimura & Kazutaka Hosoda & Takeshi Inoue & Kiyokazu Agata, 2013. "The molecular logic for planarian regeneration along the anterior–posterior axis," Nature, Nature, vol. 500(7460), pages 73-76, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12359
    DOI: 10.1038/nature12359
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