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AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes

Author

Listed:
  • Ritu Kumar

    (Weill Cornell Medical College)

  • Lauren DiMenna

    (Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute)

  • Nadine Schrode

    (Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute)

  • Ting-Chun Liu

    (Weill Cornell Medical College)

  • Philipp Franck

    (Weill Cornell Medical College)

  • Silvia Muñoz-Descalzo

    (Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute)

  • Anna-Katerina Hadjantonakis

    (Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute)

  • Ali A. Zarrin

    (Genentech)

  • Jayanta Chaudhuri

    (Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute)

  • Olivier Elemento

    (Institute for Computational Biomedicine, Weill Cornell Medical College)

  • Todd Evans

    (Weill Cornell Medical College)

Abstract

Fibroblasts deficient in the activation-induced cytidine deaminase (AID) enzyme are shown to fail to stabilize in the pluripotent state, despite initiating the expression of pluripotency genes.

Suggested Citation

  • Ritu Kumar & Lauren DiMenna & Nadine Schrode & Ting-Chun Liu & Philipp Franck & Silvia Muñoz-Descalzo & Anna-Katerina Hadjantonakis & Ali A. Zarrin & Jayanta Chaudhuri & Olivier Elemento & Todd Evans, 2013. "AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes," Nature, Nature, vol. 500(7460), pages 89-92, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12299
    DOI: 10.1038/nature12299
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