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Unusual architecture of the p7 channel from hepatitis C virus

Author

Listed:
  • Bo OuYang

    (Harvard Medical School
    State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
    National Center for Protein Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)

  • Shiqi Xie

    (Molecular Virus Unit, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China)

  • Marcelo J. Berardi

    (Harvard Medical School)

  • Xinhao Zhao

    (Molecular Virus Unit, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China)

  • Jyoti Dev

    (Harvard Medical School)

  • Wenjing Yu

    (Molecular Virus Unit, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China)

  • Bing Sun

    (Molecular Virus Unit, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology)

  • James J. Chou

    (Harvard Medical School
    State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
    National Center for Protein Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)

Abstract

The structure of the oligomeric hepatitis C virus viroporin p7 protein, solved by NMR spectroscopy, is reported; this protein can self-assemble into a channel complex that conducts cations and has a funnel-like channel architecture.

Suggested Citation

  • Bo OuYang & Shiqi Xie & Marcelo J. Berardi & Xinhao Zhao & Jyoti Dev & Wenjing Yu & Bing Sun & James J. Chou, 2013. "Unusual architecture of the p7 channel from hepatitis C virus," Nature, Nature, vol. 498(7455), pages 521-525, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12283
    DOI: 10.1038/nature12283
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    Cited by:

    1. Robert Dobosz & Jan Mućko & Ryszard Gawinecki, 2020. "Using Chou’s 5-Step Rule to Evaluate the Stability of Tautomers: Susceptibility of 2-[(Phenylimino)-methyl]-cyclohexane-1,3-diones to Tautomerization Based on the Calculated Gibbs Free Energies," Energies, MDPI, vol. 13(1), pages 1-14, January.

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