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Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1

Author

Listed:
  • Julie A. Law

    (Cell and Developmental Biology, University of California at Los Angeles
    Present address: Plant Molecular and Cellular Biology, Salk Institute, La Jolla, California 92037, USA.)

  • Jiamu Du

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Christopher J. Hale

    (Cell and Developmental Biology, University of California at Los Angeles)

  • Suhua Feng

    (Cell and Developmental Biology, University of California at Los Angeles
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California 90095, USA
    Howard Hughes Medical Institute, University of California at Los Angeles)

  • Krzysztof Krajewski

    (University of North Carolina at Chapel Hill)

  • Ana Marie S. Palanca

    (Plant Molecular and Cellular Biology, Salk Institute)

  • Brian D. Strahl

    (University of North Carolina at Chapel Hill)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Steven E. Jacobsen

    (Cell and Developmental Biology, University of California at Los Angeles
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California 90095, USA
    Howard Hughes Medical Institute, University of California at Los Angeles)

Abstract

In Arabidopsis, RNA-directed DNA methylation is a poorly understood gene silencing pathway in which small interfering RNAs generated by RNA polymerase IV (Pol-IV) target a DNA methyltransferase to its sites of action; here structural and genomic analyses demonstrate that SHH binds chromatin via repressive histone modifications and recruits Pol-IV to enable siRNA production.

Suggested Citation

  • Julie A. Law & Jiamu Du & Christopher J. Hale & Suhua Feng & Krzysztof Krajewski & Ana Marie S. Palanca & Brian D. Strahl & Dinshaw J. Patel & Steven E. Jacobsen, 2013. "Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1," Nature, Nature, vol. 498(7454), pages 385-389, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7454:d:10.1038_nature12178
    DOI: 10.1038/nature12178
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    Cited by:

    1. Yinwen Zhang & Hosung Jang & Rui Xiao & Ioanna Kakoulidou & Robert S. Piecyk & Frank Johannes & Robert J. Schmitz, 2021. "Heterochromatin is a quantitative trait associated with spontaneous epiallele formation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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