IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v497y2013i7451d10.1038_nature12138.html
   My bibliography  Save this article

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Author

Listed:
  • Cosimo Commisso

    (New York University School of Medicine)

  • Shawn M. Davidson

    (Massachusetts Institute of Technology)

  • Rengin G. Soydaner-Azeloglu

    (New York University School of Medicine)

  • Seth J. Parker

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Jurre J. Kamphorst

    (Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University)

  • Sean Hackett

    (Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University)

  • Elda Grabocka

    (New York University School of Medicine)

  • Michel Nofal

    (Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University)

  • Jeffrey A. Drebin

    (Hospital of the University of Pennsylvania)

  • Craig B. Thompson

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center)

  • Joshua D. Rabinowitz

    (Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University)

  • Christian M. Metallo

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Matthew G. Vander Heiden

    (Massachusetts Institute of Technology
    Dana-Farber Cancer Institute)

  • Dafna Bar-Sagi

    (New York University School of Medicine)

Abstract

Oncogenic Ras has previously been shown to promote macropinocytosis; here it is demonstrated that this process allows tumour cells to use extracellular proteins to generate amino acids necessary to support tumour growth.

Suggested Citation

  • Cosimo Commisso & Shawn M. Davidson & Rengin G. Soydaner-Azeloglu & Seth J. Parker & Jurre J. Kamphorst & Sean Hackett & Elda Grabocka & Michel Nofal & Jeffrey A. Drebin & Craig B. Thompson & Joshua D, 2013. "Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells," Nature, Nature, vol. 497(7451), pages 633-637, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7451:d:10.1038_nature12138
    DOI: 10.1038/nature12138
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12138
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12138?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hui Tu & Zhimeng Wang & Ye Yuan & Xilin Miao & Dong Li & Hu Guo & Yihong Yang & Huaqing Cai, 2022. "The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Edoardo Ratto & S. Roy Chowdhury & Nora S. Siefert & Martin Schneider & Marten Wittmann & Dominic Helm & Wilhelm Palm, 2022. "Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Misty Shuo Zhang & Jane Di Cui & Derek Lee & Vincent Wai-Hin Yuen & David Kung-Chun Chiu & Chi Ching Goh & Jacinth Wing-Sum Cheu & Aki Pui-Wah Tse & Macus Hao-Ran Bao & Bowie Po Yee Wong & Carrie Yili, 2022. "Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Kay Oliver Schink & Kia Wee Tan & Hélène Spangenberg & Domenica Martorana & Marte Sneeggen & Virginie Stévenin & Jost Enninga & Coen Campsteijn & Camilla Raiborg & Harald Stenmark, 2021. "The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. David Paul & Omer Stern & Yvonne Vallis & Jatinder Dhillon & Andrew Buchanan & Harvey McMahon, 2023. "Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Ella N. Hoogenboezem & Shrusti S. Patel & Justin H. Lo & Ashley B. Cavnar & Lauren M. Babb & Nora Francini & Eva F. Gbur & Prarthana Patil & Juan M. Colazo & Danielle L. Michell & Violeta M. Sanchez &, 2024. "Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:497:y:2013:i:7451:d:10.1038_nature12138. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.