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The shaping and functional consequences of the microRNA landscape in breast cancer

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  • Heidi Dvinge

    (University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Present addresses: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (H.D.); Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK (S.G.).)

  • Anna Git

    (University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Stefan Gräf

    (University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Present addresses: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (H.D.); Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK (S.G.).)

  • Mali Salmon-Divon

    (European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus
    Ariel University Center of Samaria)

  • Christina Curtis

    (University of Southern California)

  • Andrea Sottoriva

    (University of Southern California)

  • Yongjun Zhao

    (Genome Sciences Centre, BC Cancer Agency
    University of British Columbia)

  • Martin Hirst

    (Genome Sciences Centre, BC Cancer Agency
    University of British Columbia)

  • Javier Armisen

    (University of Cambridge)

  • Eric A. Miska

    (University of Cambridge)

  • Suet-Feung Chin

    (University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Elena Provenzano

    (Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre)

  • Gulisa Turashvili

    (University of British Columbia
    Molecular Oncology)

  • Andrew Green

    (School of Molecular Medical Sciences, University of Nottingham)

  • Ian Ellis

    (School of Molecular Medical Sciences, University of Nottingham)

  • Sam Aparicio

    (University of British Columbia
    Molecular Oncology)

  • Carlos Caldas

    (University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
    Cambridge Experimental Cancer Medicine Centre)

Abstract

MicroRNA profiling of 1,302 human breast tumour samples provides an overview of the miRNA landscape and its regulation, revealing context-dependent interactions, broad prognostic value of miRNA signatures and an important modulatory role for miRNAs in the biology of breast tumours devoid of copy-number aberrations.

Suggested Citation

  • Heidi Dvinge & Anna Git & Stefan Gräf & Mali Salmon-Divon & Christina Curtis & Andrea Sottoriva & Yongjun Zhao & Martin Hirst & Javier Armisen & Eric A. Miska & Suet-Feung Chin & Elena Provenzano & Gu, 2013. "The shaping and functional consequences of the microRNA landscape in breast cancer," Nature, Nature, vol. 497(7449), pages 378-382, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7449:d:10.1038_nature12108
    DOI: 10.1038/nature12108
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    Cited by:

    1. Shay Ben-Elazar & Miriam Ragle Aure & Kristin Jonsdottir & Suvi-Katri Leivonen & Vessela N Kristensen & Emiel A M Janssen & Kristine Kleivi Sahlberg & Ole Christian Lingjærde & Zohar Yakhini, 2021. "miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-24, February.
    2. Dominic Edelmann & Thomas Welchowski & Axel Benner, 2022. "A consistent version of distance covariance for right‐censored survival data and its application in hypothesis testing," Biometrics, The International Biometric Society, vol. 78(3), pages 867-879, September.

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