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A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

Author

Listed:
  • Daniele Canzio

    (University of California San Francisco
    Chemistry and Chemical Biology Graduate Program University of California San Francisco)

  • Maofu Liao

    (University of California San Francisco)

  • Nariman Naber

    (University of California San Francisco)

  • Edward Pate

    (Voiland School of Chemical Engineering and Bioengineering, Washington State University)

  • Adam Larson

    (University of California San Francisco
    Tetrad Graduate Program University of California San Francisco)

  • Shenping Wu

    (University of California San Francisco)

  • Diana B. Marina

    (University of California San Francisco
    Tetrad Graduate Program University of California San Francisco)

  • Jennifer F. Garcia

    (University of California San Francisco
    Tetrad Graduate Program University of California San Francisco)

  • Hiten D. Madhani

    (University of California San Francisco)

  • Roger Cooke

    (University of California San Francisco)

  • Peter Schuck

    (National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health)

  • Yifan Cheng

    (University of California San Francisco)

  • Geeta J. Narlikar

    (University of California San Francisco)

Abstract

The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin assembly and gene silencing.

Suggested Citation

  • Daniele Canzio & Maofu Liao & Nariman Naber & Edward Pate & Adam Larson & Shenping Wu & Diana B. Marina & Jennifer F. Garcia & Hiten D. Madhani & Roger Cooke & Peter Schuck & Yifan Cheng & Geeta J. Na, 2013. "A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly," Nature, Nature, vol. 496(7445), pages 377-381, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7445:d:10.1038_nature12032
    DOI: 10.1038/nature12032
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    Citations

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    Cited by:

    1. Zengyu Shao & Jiuwei Lu & Nelli Khudaverdyan & Jikui Song, 2024. "Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Surya K Ghosh & Daniel Jost, 2018. "How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-26, May.
    3. Tengfei Wang & Shuxiang Shi & Yuanyuan Shi & Peipei Jiang & Ganlu Hu & Qinying Ye & Zhan Shi & Kexin Yu & Chenguang Wang & Guoping Fan & Suwen Zhao & Hanhui Ma & Alex C. Y. Chang & Zhi Li & Qian Bian , 2023. "Chemical-induced phase transition and global conformational reorganization of chromatin," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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