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Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

Author

Listed:
  • Billy T. Chen

    (Intramural Research Program, National Institute on Drug Abuse)

  • Hau-Jie Yau

    (Intramural Research Program, National Institute on Drug Abuse)

  • Christina Hatch

    (Intramural Research Program, National Institute on Drug Abuse)

  • Ikue Kusumoto-Yoshida

    (Intramural Research Program, National Institute on Drug Abuse)

  • Saemi L. Cho

    (Ernest Gallo Clinic and Research Center, University of California San Francisco)

  • F. Woodward Hopf

    (Ernest Gallo Clinic and Research Center, University of California San Francisco
    University of California San Francisco)

  • Antonello Bonci

    (Intramural Research Program, National Institute on Drug Abuse
    University of California San Francisco
    Solomon H. Snyder Neuroscience Institute, Johns Hopkins School of Medicine)

Abstract

A study of compulsive drug-seeking behaviour in rats reveals that prolonged cocaine self-administration decreases prelimbic cortex activity resulting in increased compulsive drug-seeking actions; conversely, increasing activity in the prelimbic cortex decreases drug-seeking behaviour, a finding relevant to addiction treatment.

Suggested Citation

  • Billy T. Chen & Hau-Jie Yau & Christina Hatch & Ikue Kusumoto-Yoshida & Saemi L. Cho & F. Woodward Hopf & Antonello Bonci, 2013. "Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking," Nature, Nature, vol. 496(7445), pages 359-362, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7445:d:10.1038_nature12024
    DOI: 10.1038/nature12024
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    Cited by:

    1. Lun Wang & Min Gao & Qinglong Wang & Liyuan Sun & Muhammad Younus & Sixing Ma & Can Liu & Li Shi & Yang Lu & Bo Zhou & Suhua Sun & Guoqing Chen & Jie Li & Quanfeng Zhang & Feipeng Zhu & Changhe Wang &, 2023. "Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Murali Rao & Sanne Barsballe Jessen, 2019. "Transcranial Magnetic Stimulation (Rtms) In the Treatment of Cocaine use Disorder," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 11(1), pages 18-22, July.

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