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Differential stem- and progenitor-cell trafficking by prostaglandin E2

Author

Listed:
  • Jonathan Hoggatt

    (Microbiology and Immunology, Indiana University School of Medicine
    Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital)

  • Khalid S. Mohammad

    (Medicine/Endocrinology, Indiana University School of Medicine)

  • Pratibha Singh

    (Microbiology and Immunology, Indiana University School of Medicine)

  • Amber F. Hoggatt

    (Microbiology and Immunology, Indiana University School of Medicine
    Biologic Resources Laboratory, University of Illinois at Chicago)

  • Brahmananda R. Chitteti

    (Indiana University School of Medicine)

  • Jennifer M. Speth

    (Microbiology and Immunology, Indiana University School of Medicine)

  • Peirong Hu

    (Microbiology and Immunology, Indiana University School of Medicine)

  • Bradley A. Poteat

    (Indiana University School of Medicine)

  • Kayla N. Stilger

    (Microbiology and Immunology, Indiana University School of Medicine)

  • Francesca Ferraro

    (Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital)

  • Lev Silberstein

    (Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital)

  • Frankie K. Wong

    (Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital)

  • Sherif S. Farag

    (Indiana University School of Medicine)

  • Magdalena Czader

    (Pathology and Laboratory Medicine, Indiana University School of Medicine)

  • Ginger L. Milne

    (Eicosanoid Core Laboratory, Vanderbilt University)

  • Richard M. Breyer

    (Vanderbilt University)

  • Carlos H. Serezani

    (Microbiology and Immunology, Indiana University School of Medicine)

  • David T. Scadden

    (Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital)

  • Theresa A. Guise

    (Medicine/Endocrinology, Indiana University School of Medicine)

  • Edward F. Srour

    (Microbiology and Immunology, Indiana University School of Medicine
    Indiana University School of Medicine)

  • Louis M. Pelus

    (Microbiology and Immunology, Indiana University School of Medicine)

Abstract

Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.

Suggested Citation

  • Jonathan Hoggatt & Khalid S. Mohammad & Pratibha Singh & Amber F. Hoggatt & Brahmananda R. Chitteti & Jennifer M. Speth & Peirong Hu & Bradley A. Poteat & Kayla N. Stilger & Francesca Ferraro & Lev Si, 2013. "Differential stem- and progenitor-cell trafficking by prostaglandin E2," Nature, Nature, vol. 495(7441), pages 365-369, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11929
    DOI: 10.1038/nature11929
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