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CPEB1 coordinates alternative 3′-UTR formation with translational regulation

Author

Listed:
  • Felice-Alessio Bava

    (Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain)

  • Carolina Eliscovich

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain
    Present address: Albert Einstein College of Medicine, Department of Anatomy and Structural Biology, Bronx, New York 10461, USA.)

  • Pedro G. Ferreira

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Belen Miñana

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Claudia Ben-Dov

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Roderic Guigó

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Juan Valcárcel

    (Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, 08003 Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís companys 23)

  • Raúl Méndez

    (Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís companys 23)

Abstract

CPEB1 is known to regulate cytoplasmic polyadenylation, and is now shown to have a second function in the nucleus; it associates with the cleavage and polyadenylation machinery, thereby promoting usage of an upstream poly(A) signal in many messenger RNAs, and affecting alternative splicing.

Suggested Citation

  • Felice-Alessio Bava & Carolina Eliscovich & Pedro G. Ferreira & Belen Miñana & Claudia Ben-Dov & Roderic Guigó & Juan Valcárcel & Raúl Méndez, 2013. "CPEB1 coordinates alternative 3′-UTR formation with translational regulation," Nature, Nature, vol. 495(7439), pages 121-125, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7439:d:10.1038_nature11901
    DOI: 10.1038/nature11901
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    Cited by:

    1. Wenshu Zeng & Lu Yue & Kim S. W. Lam & Wenxin Zhang & Wai-Kin So & Erin H. Y. Tse & Tom H. Cheung, 2022. "CPEB1 directs muscle stem cell activation by reprogramming the translational landscape," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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