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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Author

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  • Michael T. Heneka

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
    Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE))

  • Markus P. Kummer

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Andrea Stutz

    (Institute of Innate Immunity, University of Bonn)

  • Andrea Delekate

    (Zoological Institute, Technische Universität Braunschweig)

  • Stephanie Schwartz

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Ana Vieira-Saecker

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Angelika Griep

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Daisy Axt

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Anita Remus

    (Zoological Institute, Technische Universität Braunschweig)

  • Te-Chen Tzeng

    (University of Massachusetts Medical School)

  • Ellen Gelpi

    (Neurological Tissue Bank, University of Barcelona-Hospital Clinic, IDIBAPS, 08036 Barcelona, Spain)

  • Annett Halle

    (Center for Advanced European Studies and Research-CAESAR)

  • Martin Korte

    (Zoological Institute, Technische Universität Braunschweig
    Helmholtz-Center for Infection Research, HZI, AG NIND, 38124 Braunschweig, Germany)

  • Eicke Latz

    (Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
    Institute of Innate Immunity, University of Bonn
    University of Massachusetts Medical School)

  • Douglas T. Golenbock

    (University of Massachusetts Medical School)

Abstract

Alzheimer’s-prone mice deficient in NLRP3 or caspase-1 fail to develop learning deficits and show reduced neuropathology.

Suggested Citation

  • Michael T. Heneka & Markus P. Kummer & Andrea Stutz & Andrea Delekate & Stephanie Schwartz & Ana Vieira-Saecker & Angelika Griep & Daisy Axt & Anita Remus & Te-Chen Tzeng & Ellen Gelpi & Annett Halle , 2013. "NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice," Nature, Nature, vol. 493(7434), pages 674-678, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11729
    DOI: 10.1038/nature11729
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    Cited by:

    1. Vicky Chou & Richard V. Pearse & Aimee J. Aylward & Nancy Ashour & Mariko Taga & Gizem Terzioglu & Masashi Fujita & Seeley B. Fancher & Alina Sigalov & Courtney R. Benoit & Hyo Lee & Matti Lam & Nicho, 2023. "INPP5D regulates inflammasome activation in human microglia," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Dao-Gong Zhang & Wen-Qian Yu & Jia-Hui Liu & Li-Gang Kong & Na Zhang & Yong-Dong Song & Xiao-Fei Li & Zhao-Min Fan & Ya-Feng Lyu & Na Li & Hai-Bo Wang, 2023. "Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Ewa Rudnicka-Drożak & Paulina Drożak & Grzegorz Mizerski & Tomasz Zaborowski & Barbara Ślusarska & Grzegorz Nowicki & Martyna Drożak, 2023. "Links between COVID-19 and Alzheimer’s Disease—What Do We Already Know?," IJERPH, MDPI, vol. 20(3), pages 1-15, January.
    4. Noah R. Johnson & Peng Yuan & Erika Castillo & T. Peter Lopez & Weizhou Yue & Annalise Bond & Brianna M. Rivera & Miranda C. Sullivan & Masakazu Hirouchi & Kurt Giles & Atsushi Aoyagi & Carlo Condello, 2023. "CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    5. Loreta Strumylaite & Rima Kregzdyte & Odeta Kucikiene & Dale Baranauskiene & Vaida Simakauskiene & Rima Naginiene & Gyte Damuleviciene & Vita Lesauskaite & Reda Zemaitiene, 2022. "Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine," IJERPH, MDPI, vol. 19(12), pages 1-11, June.

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