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Metabolism of inflammation limited by AMPK and pseudo-starvation

Author

Listed:
  • Luke A. J. O'Neill

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • D. Grahame Hardie

    (College of Life Sciences, University of Dundee)

Abstract

Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1β and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.

Suggested Citation

  • Luke A. J. O'Neill & D. Grahame Hardie, 2013. "Metabolism of inflammation limited by AMPK and pseudo-starvation," Nature, Nature, vol. 493(7432), pages 346-355, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11862
    DOI: 10.1038/nature11862
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