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Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori

Author

Listed:
  • David Strugatsky

    (David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System)

  • Reginald McNulty

    (University of California
    Present address: Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.)

  • Keith Munson

    (David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System)

  • Chiung-Kuang Chen

    (University of California)

  • S. Michael Soltis

    (Stanford Synchrotron Radiation Lightsource, 2575 Sand Hill Road)

  • George Sachs

    (David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System)

  • Hartmut Luecke

    (University of California
    Center for Biomembrane Systems, University of California
    University of California
    University of California)

Abstract

The crystal structure of the inner-membrane urea channel HpUreI from Helicobacter pylori, the causative organism of peptic ulcers, reveals how the channel selectively transports urea across the membrane and buffers the pathogen’s periplasmic pH against the acidic gastric environment.

Suggested Citation

  • David Strugatsky & Reginald McNulty & Keith Munson & Chiung-Kuang Chen & S. Michael Soltis & George Sachs & Hartmut Luecke, 2013. "Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori," Nature, Nature, vol. 493(7431), pages 255-258, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11684
    DOI: 10.1038/nature11684
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