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Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin

Author

Listed:
  • Alexandra McAleenan

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Andres Clemente-Blanco

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Violeta Cordon-Preciado

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Nicholas Sen

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Miguel Esteras

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Adam Jarmuz

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Luis Aragón

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

Abstract

Cohesin, which tethers sister chromatids together, is found to be cleaved by separase after DNA damage, resulting in cohesin dissociation and allowing for post-replicative repair of DNA double-strand breaks.

Suggested Citation

  • Alexandra McAleenan & Andres Clemente-Blanco & Violeta Cordon-Preciado & Nicholas Sen & Miguel Esteras & Adam Jarmuz & Luis Aragón, 2013. "Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin," Nature, Nature, vol. 493(7431), pages 250-254, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11630
    DOI: 10.1038/nature11630
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