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Restriction of intestinal stem cell expansion and the regenerative response by YAP

Author

Listed:
  • Evan R. Barry

    (Children’s Hospital
    Harvard University
    Harvard Stem Cell Institute)

  • Teppei Morikawa

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Brian L. Butler

    (Children’s Hospital
    Harvard University)

  • Kriti Shrestha

    (Children’s Hospital)

  • Rosemarie de la Rosa

    (Children’s Hospital)

  • Kelley S. Yan

    (Stanford University)

  • Charles S. Fuchs

    (Dana-Farber Cancer Institute and Harvard Medical School
    Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School)

  • Scott T. Magness

    (The University of North Carolina at Chapel Hill)

  • Ron Smits

    (Erasmus MC, 3000 CA Rotterdam, The Netherlands)

  • Shuji Ogino

    (Dana-Farber Cancer Institute and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School)

  • Calvin J. Kuo

    (Stanford University)

  • Fernando D. Camargo

    (Children’s Hospital
    Harvard University
    Harvard Stem Cell Institute)

Abstract

YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the mouse intestine, suggesting that it may function as a tumour suppressor in colon cancer.

Suggested Citation

  • Evan R. Barry & Teppei Morikawa & Brian L. Butler & Kriti Shrestha & Rosemarie de la Rosa & Kelley S. Yan & Charles S. Fuchs & Scott T. Magness & Ron Smits & Shuji Ogino & Calvin J. Kuo & Fernando D. , 2013. "Restriction of intestinal stem cell expansion and the regenerative response by YAP," Nature, Nature, vol. 493(7430), pages 106-110, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7430:d:10.1038_nature11693
    DOI: 10.1038/nature11693
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    Cited by:

    1. Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Zhenqiang Sun & Ruiwei Xu & Xiayu Li & Weiguo Ren & Chunlin Ou & Qisan Wang & Han Zhang & Xuemei Zhang & Jian Ma & Haijiang Wang & Guiyuan Li, 2015. "Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    3. Jong Hoon Won & Jacob S. Choi & Joon-Il Jun, 2022. "CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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