IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v490y2012i7420d10.1038_nature11438.html
   My bibliography  Save this article

The aged niche disrupts muscle stem cell quiescence

Author

Listed:
  • Joe V. Chakkalakal

    (Center of Regenerative Medicine, Massachusetts General Hospital)

  • Kieran M. Jones

    (King’s College London, Guy’s Campus, London SE1 9RT, UK)

  • M. Albert Basson

    (King’s College London, Guy’s Campus, London SE1 9RT, UK)

  • Andrew S. Brack

    (Center of Regenerative Medicine, Massachusetts General Hospital
    Harvard Stem Cell Institute, 135 Massachusetts Avenue
    Harvard Medical School, 25 Shattuck Street)

Abstract

The niche is a conserved regulator of stem cell quiescence and function. During ageing, stem cell function declines. To what extent and by what means age-related changes within the niche contribute to this phenomenon are unknown. Here we demonstrate that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity. We show in mice that relatively dormant aged satellite cells robustly express sprouty 1 (Spry1), an inhibitor of fibroblast growth factor (FGF) signalling. Increasing FGF signalling in aged satellite cells under homeostatic conditions by removing Spry1 results in the loss of quiescence, satellite cell depletion and diminished regenerative capacity. Conversely, reducing niche-derived FGF activity through inhibition of Fgfr1 signalling or overexpression of Spry1 in satellite cells prevents their depletion. These experiments identify an age-dependent change in the stem cell niche that directly influences stem cell quiescence and function.

Suggested Citation

  • Joe V. Chakkalakal & Kieran M. Jones & M. Albert Basson & Andrew S. Brack, 2012. "The aged niche disrupts muscle stem cell quiescence," Nature, Nature, vol. 490(7420), pages 355-360, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11438
    DOI: 10.1038/nature11438
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11438
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11438?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. David E. Lee & Lauren K. McKay & Akshay Bareja & Yongwu Li & Alastair Khodabukus & Nenad Bursac & Gregory A. Taylor & Gurpreet S. Baht & James P. White, 2022. "Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Brendan Evano & Diljeet Gill & Irene Hernando-Herraez & Glenda Comai & Thomas M Stubbs & Pierre-Henri Commere & Wolf Reik & Shahragim Tajbakhsh, 2020. "Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation," PLOS Genetics, Public Library of Science, vol. 16(10), pages 1-21, October.
    3. Adelaida R. Palla & Keren I. Hilgendorf & Ann V. Yang & Jaclyn P. Kerr & Aaron C. Hinken & Janos Demeter & Peggy Kraft & Nancie A. Mooney & Nora Yucel & David M. Burns & Yu Xin Wang & Peter K. Jackson, 2022. "Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Jeffrey C. Gerrard & Jamison P. Hay & Ryan N. Adams & James C. Williams & Joshua R. Huot & Kaitlin M. Weathers & Joseph S. Marino & Susan T. Arthur, 2021. "Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease," IJERPH, MDPI, vol. 18(23), pages 1-20, November.
    5. Felicia Lazure & Rick Farouni & Korin Sahinyan & Darren M. Blackburn & Aldo Hernández-Corchado & Gabrielle Perron & Tianyuan Lu & Adrien Osakwe & Jiannis Ragoussis & Colin Crist & Theodore J. Perkins , 2023. "Transcriptional reprogramming of skeletal muscle stem cells by the niche environment," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11438. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.