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Functional interactions between the gut microbiota and host metabolism

Author

Listed:
  • Valentina Tremaroli

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital
    University of Gothenburg)

  • Fredrik Bäckhed

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital
    University of Gothenburg
    Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen)

Abstract

The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.

Suggested Citation

  • Valentina Tremaroli & Fredrik Bäckhed, 2012. "Functional interactions between the gut microbiota and host metabolism," Nature, Nature, vol. 489(7415), pages 242-249, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11552
    DOI: 10.1038/nature11552
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    1. Yongli Qin & Lina Jia & Huijiao Liu & Wenqiang Ma & Xinmin Ren & Haifeng Li & Yuanwu Liu & Haiwen Li & Shuoqian Ma & Mei Liu & Pingping Li & Jinghua Yan & Jiyan Zhang & Yangdong Guo & Hua You & Yan Gu, 2021. "Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Oriol Juanola & Sebastián Martínez-López & Rubén Francés & Isabel Gómez-Hurtado, 2021. "Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors," IJERPH, MDPI, vol. 18(10), pages 1-24, May.
    3. Jing-Hua Wang & Bong-Soo Kim & Kyungsun Han & Hojun Kim, 2017. "Ephedra -Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats," IJERPH, MDPI, vol. 14(6), pages 1-20, May.
    4. Pasquale Comberiati & Maria Di Cicco & Francesco Paravati & Umberto Pelosi & Alessandro Di Gangi & Stefania Arasi & Simona Barni & Davide Caimmi & Carla Mastrorilli & Amelia Licari & Fernanda Chiera, 2021. "The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis," IJERPH, MDPI, vol. 18(22), pages 1-20, November.
    5. Julie Reygner & Claire Joly Condette & Aurélia Bruneau & Stéphane Delanaud & Larbi Rhazi & Flore Depeint & Latifa Abdennebi-Najar & Veronique Bach & Camille Mayeur & Hafida Khorsi-Cauet, 2016. "Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME ® Model," IJERPH, MDPI, vol. 13(11), pages 1-18, November.
    6. Kang Li & Zeng Dan & Luobu Gesang & Hong Wang & Yongjian Zhou & Yanlei Du & Yi Ren & Yixiang Shi & Yuqiang Nie, 2016. "Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-16, May.
    7. Giulia Angelini & Lidia Castagneto-Gissey & Serenella Salinari & Alessandro Bertuzzi & Danila Anello & Meenakshi Pradhan & Marlen Zschätzsch & Paul Ritter & Carel W. Le Roux & Francesco Rubino & Nicol, 2022. "Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    8. Gregory E Miller & Phillip A Engen & Patrick M Gillevet & Maliha Shaikh & Masoumeh Sikaroodi & Christopher B Forsyth & Ece Mutlu & Ali Keshavarzian, 2016. "Lower Neighborhood Socioeconomic Status Associated with Reduced Diversity of the Colonic Microbiota in Healthy Adults," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-17, February.
    9. Vinod Nikhra, 2019. "The Novel Dimensions of Cardio-Metabolic Health Gut Microbiota, Dysbiosis and its Fallouts," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 11(1), pages 28-37, June.
    10. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.

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