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Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

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  • Yuji Shiba

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
    Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan)

  • Sarah Fernandes

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Wei-Zhong Zhu

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Dominic Filice

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Veronica Muskheli

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Jonathan Kim

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Nathan J. Palpant

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Jay Gantz

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Kara White Moyes

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Hans Reinecke

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Benjamin Van Biber

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

  • Todd Dardas

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA)

  • John L. Mignone

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA)

  • Atsushi Izawa

    (Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan)

  • Ramy Hanna

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA)

  • Mohan Viswanathan

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA)

  • Joseph D. Gold

    (Geron Corporation, 230 Constitution Drive)

  • Michael I. Kotlikoff

    (College of Veterinary Medicine, Cornell University)

  • Narine Sarvazyan

    (The George Washington University, 2300 I Street NW, Washington DC 20037 USA)

  • Matthew W. Kay

    (The George Washington University, 2300 I Street NW, Washington DC 20037 USA
    The George Washington University, 2300 I Street NW, Washington DC 20037 USA)

  • Charles E. Murry

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA)

  • Michael A. Laflamme

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA)

Abstract

A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes.

Suggested Citation

  • Yuji Shiba & Sarah Fernandes & Wei-Zhong Zhu & Dominic Filice & Veronica Muskheli & Jonathan Kim & Nathan J. Palpant & Jay Gantz & Kara White Moyes & Hans Reinecke & Benjamin Van Biber & Todd Dardas &, 2012. "Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts," Nature, Nature, vol. 489(7415), pages 322-325, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11317
    DOI: 10.1038/nature11317
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    Cited by:

    1. Mina Ogawa & Jia-Xin Jiang & Sunny Xia & Donghe Yang & Avrilynn Ding & Onofrio Laselva & Marcela Hernandez & Changyi Cui & Yuichiro Higuchi & Hiroshi Suemizu & Craig Dorrell & Markus Grompe & Christin, 2021. "Generation of functional ciliated cholangiocytes from human pluripotent stem cells," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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