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Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

Author

Listed:
  • Claudia A. Doege

    (Taub Institute for Aging, Columbia University)

  • Keiichi Inoue

    (Taub Institute for Aging, Columbia University)

  • Toru Yamashita

    (Taub Institute for Aging, Columbia University)

  • David B. Rhee

    (Taub Institute for Aging, Columbia University)

  • Skylar Travis

    (Taub Institute for Aging, Columbia University)

  • Ryousuke Fujita

    (Taub Institute for Aging, Columbia University)

  • Paolo Guarnieri

    (Biomedical Informatics Shared Resources, Columbia University
    Herbert Irving Comprehensive Cancer Center, Columbia University)

  • Govind Bhagat

    (Taub Institute for Aging, Columbia University
    Herbert Irving Comprehensive Cancer Center, Columbia University)

  • William B. Vanti

    (Taub Institute for Aging, Columbia University)

  • Alan Shih

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Ross L. Levine

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Sara Nik

    (Stony Brook University)

  • Emily I. Chen

    (Stony Brook University
    Stony Brook University Proteomics Center, School Of Medicine)

  • Asa Abeliovich

    (Taub Institute for Aging, Columbia University)

Abstract

Parp1 and Tet2 mediate essential epigenetic remodelling events in an early phase of induced pluripotent stem cell reprogramming, thus directing subsequent induction of the pluripotency loci.

Suggested Citation

  • Claudia A. Doege & Keiichi Inoue & Toru Yamashita & David B. Rhee & Skylar Travis & Ryousuke Fujita & Paolo Guarnieri & Govind Bhagat & William B. Vanti & Alan Shih & Ross L. Levine & Sara Nik & Emily, 2012. "Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2," Nature, Nature, vol. 488(7413), pages 652-655, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11333
    DOI: 10.1038/nature11333
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