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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Author

Listed:
  • Masato Sasaki

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Christiane B. Knobbe

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
    Heinrich Heine University, 40225 Düsseldorf, Germany)

  • Joshua C. Munger

    (School of Medicine and Dentistry, University of Rochester)

  • Evan F. Lind

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Dirk Brenner

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Anne Brüstle

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Isaac S. Harris

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
    University of Toronto, Toronto, Ontario M5G 2C1, Canada)

  • Roxanne Holmes

    (Sunnybrook Research Institute, University of Toronto, Toronto, Ontario M4N 3M5, Canada)

  • Andrew Wakeham

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Jillian Haight

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Annick You-Ten

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Wanda Y. Li

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Stefanie Schalm

    (Agios Pharmaceuticals Incorporated)

  • Shinsan M. Su

    (Agios Pharmaceuticals Incorporated)

  • Carl Virtanen

    (University Health Network Microarray Center, Toronto, Ontario M5S 1A8, Canada)

  • Guido Reifenberger

    (Heinrich Heine University, 40225 Düsseldorf, Germany)

  • Pamela S. Ohashi

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada)

  • Dwayne L. Barber

    (University of Toronto, Toronto, Ontario M5G 2C1, Canada)

  • Maria E. Figueroa

    (University of Michigan)

  • Ari Melnick

    (Weill Cornell Medical College, Cornell University)

  • Juan-Carlos Zúñiga-Pflücker

    (Sunnybrook Research Institute, University of Toronto, Toronto, Ontario M4N 3M5, Canada)

  • Tak W. Mak

    (The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
    University of Toronto, Toronto, Ontario M5G 2C1, Canada)

Abstract

Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation are described, in a new model that should help in investigating the links between mutant IDH1 and leukaemia.

Suggested Citation

  • Masato Sasaki & Christiane B. Knobbe & Joshua C. Munger & Evan F. Lind & Dirk Brenner & Anne Brüstle & Isaac S. Harris & Roxanne Holmes & Andrew Wakeham & Jillian Haight & Annick You-Ten & Wanda Y. Li, 2012. "IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics," Nature, Nature, vol. 488(7413), pages 656-659, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11323
    DOI: 10.1038/nature11323
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