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APJ acts as a dual receptor in cardiac hypertrophy

Author

Listed:
  • Maria Cecilia Scimia

    (Sanford-Burnham Medical Research Institute)

  • Cecilia Hurtado

    (Sanford-Burnham Medical Research Institute)

  • Saugata Ray

    (Sanford-Burnham Medical Research Institute)

  • Scott Metzler

    (School of Medicine, Stanford University)

  • Ke Wei

    (Sanford-Burnham Medical Research Institute)

  • Jianming Wang

    (Sanford-Burnham Medical Research Institute)

  • Chris E. Woods

    (School of Medicine, Stanford University)

  • Nicole H. Purcell

    (University of California)

  • Daniele Catalucci

    (Biomedical and Genetic Research Institute, National Research Council, via Fantoli 16/15, 20138, Milan, Italy
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy)

  • Takeshi Akasaka

    (Sanford-Burnham Medical Research Institute)

  • Orlando F. Bueno

    (Wyeth Pharmaceutical)

  • George P. Vlasuk

    (Wyeth Pharmaceutical
    Present address: Sirtris, a GSK Company, Cambridge, Massachusetts 02139, USA.)

  • Perla Kaliman

    (Institute of Biomedical Research, August Pi i Sunyer (IDIBAPS), E-08036 Barcelona, Spain)

  • Rolf Bodmer

    (Sanford-Burnham Medical Research Institute)

  • Layton H. Smith

    (Sanford-Burnham Medical Research Institute)

  • Euan Ashley

    (School of Medicine, Stanford University)

  • Mark Mercola

    (Sanford-Burnham Medical Research Institute)

  • Joan Heller Brown

    (University of California)

  • Pilar Ruiz-Lozano

    (Sanford-Burnham Medical Research Institute
    School of Medicine, Stanford University)

Abstract

APJ is shown to be a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin, a finding that is important for the development of APJ agonists to treat heart failure.

Suggested Citation

  • Maria Cecilia Scimia & Cecilia Hurtado & Saugata Ray & Scott Metzler & Ke Wei & Jianming Wang & Chris E. Woods & Nicole H. Purcell & Daniele Catalucci & Takeshi Akasaka & Orlando F. Bueno & George P. , 2012. "APJ acts as a dual receptor in cardiac hypertrophy," Nature, Nature, vol. 488(7411), pages 394-398, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7411:d:10.1038_nature11263
    DOI: 10.1038/nature11263
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