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Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells

Author

Listed:
  • Ping Wei

    (University of California San Francisco
    Howard Hughes Medical Institute, University of California San Francisco)

  • Wilson W. Wong

    (University of California San Francisco
    Howard Hughes Medical Institute, University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco
    Present addresses: Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA (W.W.W.); Department of Pulmonology and Critical Care Medicine, Northwest Permanente P.C., 10180 SE Sunnyside Road, Clackamas, Oregon 97015, USA (E.E.C.); Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada (S.G.P.).)

  • Jason S. Park

    (University of California San Francisco
    Howard Hughes Medical Institute, University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco)

  • Ethan E. Corcoran

    (Howard Hughes Medical Institute, University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco
    University of California San Francisco
    Present addresses: Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA (W.W.W.); Department of Pulmonology and Critical Care Medicine, Northwest Permanente P.C., 10180 SE Sunnyside Road, Clackamas, Oregon 97015, USA (E.E.C.); Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada (S.G.P.).)

  • Sergio G. Peisajovich

    (University of California San Francisco
    Howard Hughes Medical Institute, University of California San Francisco
    Present addresses: Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA (W.W.W.); Department of Pulmonology and Critical Care Medicine, Northwest Permanente P.C., 10180 SE Sunnyside Road, Clackamas, Oregon 97015, USA (E.E.C.); Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada (S.G.P.).)

  • James J. Onuffer

    (University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco)

  • Arthur Weiss

    (Howard Hughes Medical Institute, University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco
    University of California San Francisco)

  • Wendell A. Lim

    (University of California San Francisco
    Howard Hughes Medical Institute, University of California San Francisco
    The Cell Propulsion Laboratory, University of California San Francisco)

Abstract

Virulence factors from two bacteria are used to reprogram intracellular signalling in yeast and immune T cells, illustrating how pathogens can provide a toolkit to engineer cells for biotechnological or therapeutic applications.

Suggested Citation

  • Ping Wei & Wilson W. Wong & Jason S. Park & Ethan E. Corcoran & Sergio G. Peisajovich & James J. Onuffer & Arthur Weiss & Wendell A. Lim, 2012. "Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells," Nature, Nature, vol. 488(7411), pages 384-388, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7411:d:10.1038_nature11259
    DOI: 10.1038/nature11259
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