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The mutational landscape of lethal castration-resistant prostate cancer

Author

Listed:
  • Catherine S. Grasso

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Yi-Mi Wu

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Dan R. Robinson

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xuhong Cao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School)

  • Saravana M. Dhanasekaran

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Amjad P. Khan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Michael J. Quist

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xiaojun Jing

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Robert J. Lonigro

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • J. Chad Brenner

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Irfan A. Asangani

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Bushra Ateeq

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Sang Y. Chun

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Javed Siddiqui

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Lee Sam

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Matt Anstett

    (Compendia Bioscience)

  • Rohit Mehra

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • John R. Prensner

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Nallasivam Palanisamy

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Gregory A. Ryslik

    (Yale School of Public Health)

  • Fabio Vandin

    (Brown University)

  • Benjamin J. Raphael

    (Brown University)

  • Lakshmi P. Kunju

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Daniel R. Rhodes

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Compendia Bioscience)

  • Kenneth J. Pienta

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School)

  • Arul M. Chinnaiyan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Scott A. Tomlins

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

Abstract

Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing recurrent mutations in multiple chromatin/histone modifying genes, as well as genes involved in androgen signalling.

Suggested Citation

  • Catherine S. Grasso & Yi-Mi Wu & Dan R. Robinson & Xuhong Cao & Saravana M. Dhanasekaran & Amjad P. Khan & Michael J. Quist & Xiaojun Jing & Robert J. Lonigro & J. Chad Brenner & Irfan A. Asangani & B, 2012. "The mutational landscape of lethal castration-resistant prostate cancer," Nature, Nature, vol. 487(7406), pages 239-243, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7406:d:10.1038_nature11125
    DOI: 10.1038/nature11125
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    Citations

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    Cited by:

    1. Chih-Wei Chou & Chia-Nung Hung & Cheryl Hsiang-Ling Chiu & Xi Tan & Meizhen Chen & Chien-Chin Chen & Moawiz Saeed & Che-Wei Hsu & Michael A. Liss & Chiou-Miin Wang & Zhao Lai & Nathaniel Alvarez & Paw, 2023. "Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Chandrani Mukhopadhyay & Chenyi Yang & Limei Xu & Deli Liu & Yu Wang & Dennis Huang & Lesa Dayal Deonarine & Joanna Cyrta & Elai Davicioni & Andrea Sboner & Brian. D. Robinson & Arul M. Chinnaiyan & M, 2021. "G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Michael Fraser & Julie Livingstone & Jeffrey L. Wrana & Antonio Finelli & Housheng Hansen He & Theodorus van der Kwast & Alexandre R. Zlotta & Robert G. Bristow & Paul C. Boutros, 2021. "Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Huiqiang Cai & Bin Zhang & Johanne Ahrenfeldt & Justin V. Joseph & Maria Riedel & Zongliang Gao & Sofie K. Thomsen & Ditte S. Christensen & Rasmus O. Bak & Henrik Hager & Mikkel H. Vendelbo & Xin Gao , 2024. "CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Yiwu Yan & Bo Zhou & Chen Qian & Alex Vasquez & Mohini Kamra & Avradip Chatterjee & Yeon-Joo Lee & Xiaopu Yuan & Leigh Ellis & Dolores Vizio & Edwin M. Posadas & Natasha Kyprianou & Beatrice S. Knudse, 2022. "Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Xiaoguang Pan & Kunli Qu & Hao Yuan & Xi Xiang & Christian Anthon & Liubov Pashkova & Xue Liang & Peng Han & Giulia I. Corsi & Fengping Xu & Ping Liu & Jiayan Zhong & Yan Zhou & Tao Ma & Hui Jiang & J, 2022. "Massively targeted evaluation of therapeutic CRISPR off-targets in cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Jeroen Kneppers & Tesa M. Severson & Joseph C. Siefert & Pieter Schol & Stacey E. P. Joosten & Ivan Pak Lok Yu & Chia-Chi Flora Huang & Tunç Morova & Umut Berkay Altıntaş & Claudia Giambartolomei & Ji, 2022. "Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Sandra M. Rocha & Sílvia Socorro & Luís A. Passarinha & Cláudio J. Maia, 2022. "Comprehensive Landscape of STEAP Family Members Expression in Human Cancers: Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis," Data, MDPI, vol. 7(5), pages 1-48, May.

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