IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v487y2012i7405d10.1038_nature11149.html
   My bibliography  Save this article

Programmable single-cell mammalian biocomputers

Author

Listed:
  • Simon Ausländer

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • David Ausländer

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Marius Müller

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Markus Wieland

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Martin Fussenegger

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
    Faculty of Science, University of Basel, Mattenstrasse 26, CH-4058 Basel, Switzerland)

Abstract

In synthetic biology, the use of regulatory proteins that bind either DNA or RNA to reprogram mammalian cellular functions allows a variety of computational ‘logic circuits’ to be built in a plug-and-play manner, which may pave the way for precise and robust control of future gene-based and cell-based therapies.

Suggested Citation

  • Simon Ausländer & David Ausländer & Marius Müller & Markus Wieland & Martin Fussenegger, 2012. "Programmable single-cell mammalian biocomputers," Nature, Nature, vol. 487(7405), pages 123-127, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11149
    DOI: 10.1038/nature11149
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11149
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11149?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shunsuke Kawasaki & Hiroki Ono & Moe Hirosawa & Takeru Kuwabara & Shunsuke Sumi & Suji Lee & Knut Woltjen & Hirohide Saito, 2023. "Programmable mammalian translational modulators by CRISPR-associated proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Yafeng Wang & Guiquan Zhang & Qingzhou Meng & Shisheng Huang & Panpan Guo & Qibin Leng & Lingyun Sun & Geng Liu & Xingxu Huang & Jianghuai Liu, 2022. "Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Linlin Tang & Zhijin Tian & Jin Cheng & Yijing Zhang & Yongxiu Song & Yan Liu & Jinghao Wang & Pengfei Zhang & Yonggang Ke & Friedrich C. Simmel & Jie Song, 2023. "Circular single-stranded DNA as switchable vector for gene expression in mammalian cells," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Breanna DiAndreth & Noreen Wauford & Eileen Hu & Sebastian Palacios & Ron Weiss, 2022. "PERSIST platform provides programmable RNA regulation using CRISPR endoRNases," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11149. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.