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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

Author

Listed:
  • Alejandro A. Pezzulo

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Xiao Xiao Tang

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa
    Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Mark J. Hoegger

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Mahmoud H. Abou Alaiwa

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Shyam Ramachandran

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Thomas O. Moninger

    (The Central Electron Microscopy Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Phillip H. Karp

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa
    Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Christine L. Wohlford-Lenane

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Henk P. Haagsman

    (Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands)

  • Martin van Eijk

    (Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands)

  • Botond Bánfi

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Alexander R. Horswill

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • David A. Stoltz

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Paul B. McCray

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Michael J. Welsh

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa
    Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa
    Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

  • Joseph Zabner

    (Roy J. and Lucille A. Carver College of Medicine, University of Iowa)

Abstract

In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.

Suggested Citation

  • Alejandro A. Pezzulo & Xiao Xiao Tang & Mark J. Hoegger & Mahmoud H. Abou Alaiwa & Shyam Ramachandran & Thomas O. Moninger & Phillip H. Karp & Christine L. Wohlford-Lenane & Henk P. Haagsman & Martin , 2012. "Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung," Nature, Nature, vol. 487(7405), pages 109-113, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11130
    DOI: 10.1038/nature11130
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