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SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

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  • Matthew F. Barber

    (Stanford University, Stanford, California 94305, USA
    Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Present addresses: Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA (M.F.B.); R&D Division, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo 140-8710, Japan (E.M.-K.); Department of Oral and Maxillofacial Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan (M.K.).)

  • Eriko Michishita-Kioi

    (Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Present addresses: Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA (M.F.B.); R&D Division, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo 140-8710, Japan (E.M.-K.); Department of Oral and Maxillofacial Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan (M.K.).)

  • Yuanxin Xi

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Luisa Tasselli

    (Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Mitomu Kioi

    (Stanford University, Stanford, California 94305, USA
    Present addresses: Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA (M.F.B.); R&D Division, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo 140-8710, Japan (E.M.-K.); Department of Oral and Maxillofacial Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan (M.K.).)

  • Zarmik Moqtaderi

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Ruth I. Tennen

    (Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Cancer Biology Program, Stanford University, Stanford, California 94305, USA)

  • Silvana Paredes

    (Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Nicolas L. Young

    (Princeton University, Princeton, New Jersey 08544, USA)

  • Kaifu Chen

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Kevin Struhl

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Benjamin A. Garcia

    (Princeton University, Princeton, New Jersey 08544, USA)

  • Or Gozani

    (Stanford University, Stanford, California 94305, USA)

  • Wei Li

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Katrin F. Chua

    (Gerontology, and Metabolism, Stanford University, Stanford, California 94305, USA
    Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Cancer Biology Program, Stanford University, Stanford, California 94305, USA)

Abstract

SIRT7 is an H3K18Ac-selective deacetylase that has a pivotal role in chromatin regulation, maintenance of cellular transformation programs and tumour formation in vivo.

Suggested Citation

  • Matthew F. Barber & Eriko Michishita-Kioi & Yuanxin Xi & Luisa Tasselli & Mitomu Kioi & Zarmik Moqtaderi & Ruth I. Tennen & Silvana Paredes & Nicolas L. Young & Kaifu Chen & Kevin Struhl & Benjamin A., 2012. "SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation," Nature, Nature, vol. 487(7405), pages 114-118, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11043
    DOI: 10.1038/nature11043
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    Cited by:

    1. Yu Tao & Yuan Zhang & Xiaohong Jin & Nan Hua & Hong Liu & Renfei Qi & Zitong Huang & Yufang Sun & Dongsheng Jiang & Terrance P. Snutch & Xinghong Jiang & Jin Tao, 2023. "Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Ke Zheng & Nannan Sha & Guofang Hou & Zhuyun Leng & Qin Zhao & Li Zhang & Lingnan He & Meidong Xu & Yuhui Jiang & Tao Chen, 2023. "IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Sneha Mishra & Claudia Cosentino & Ankit Kumar Tamta & Danish Khan & Shalini Srinivasan & Venkatraman Ravi & Elena Abbotto & Bangalore Prabhashankar Arathi & Shweta Kumar & Aditi Jain & Anand S. Ramai, 2022. "Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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