IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v485y2012i7399d10.1038_nature11087.html
   My bibliography  Save this article

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Author

Listed:
  • Robert D. Bell

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
    Aab Cardiovascular Research Institute, University of Rochester Medical Center)

  • Ethan A. Winkler

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • Itender Singh

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • Abhay P. Sagare

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • Rashid Deane

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • Zhenhua Wu

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • David M. Holtzman

    (Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Christer Betsholtz

    (Karolinska Institutet, Stockholm SE-171 77, Sweden)

  • Annika Armulik

    (Karolinska Institutet, Stockholm SE-171 77, Sweden
    Institute of Neuropathology, University Hospital Zürich, CH-8091, Zürich, Switzerland)

  • Jan Sallstrom

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center)

  • Bradford C. Berk

    (Aab Cardiovascular Research Institute, University of Rochester Medical Center)

  • Berislav V. Zlokovic

    (Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
    Center for Neurodegeneration and Regeneration, University of Southern California, Keck School of Medicine)

Abstract

The APOE4-mediated proinflammatory pathway is shown to initiate blood–brain barrier breakdown and resulting neurodegeneration in transgenic mice.

Suggested Citation

  • Robert D. Bell & Ethan A. Winkler & Itender Singh & Abhay P. Sagare & Rashid Deane & Zhenhua Wu & David M. Holtzman & Christer Betsholtz & Annika Armulik & Jan Sallstrom & Bradford C. Berk & Berislav , 2012. "Apolipoprotein E controls cerebrovascular integrity via cyclophilin A," Nature, Nature, vol. 485(7399), pages 512-516, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11087
    DOI: 10.1038/nature11087
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11087
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11087?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11087. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.