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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

Author

Listed:
  • Stephanie C. Eisenbarth

    (Yale University School of Medicine)

  • Adam Williams

    (Yale University School of Medicine)

  • Oscar R. Colegio

    (Yale University School of Medicine)

  • Hailong Meng

    (Yale University School of Medicine)

  • Till Strowig

    (Yale University School of Medicine)

  • Anthony Rongvaux

    (Yale University School of Medicine)

  • Jorge Henao-Mejia

    (Yale University School of Medicine)

  • Christoph A. Thaiss

    (Yale University School of Medicine)

  • Sophie Joly

    (Inflammation Program, University of Iowa)

  • David G. Gonzalez

    (Yale University School of Medicine)

  • Lan Xu

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Lauren A. Zenewicz

    (Yale University School of Medicine)

  • Ann M. Haberman

    (Yale University School of Medicine)

  • Eran Elinav

    (Yale University School of Medicine)

  • Steven H. Kleinstein

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Fayyaz S. Sutterwala

    (Inflammation Program, University of Iowa
    Veterans Affairs Medical Center)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine)

Abstract

Dendritic cells in mice lacking NLRP10 are defective in exiting inflamed tissue, leading to impaired adaptive immunity; this could have a profound impact on the approach to treating allergic and autoimmune diseases.

Suggested Citation

  • Stephanie C. Eisenbarth & Adam Williams & Oscar R. Colegio & Hailong Meng & Till Strowig & Anthony Rongvaux & Jorge Henao-Mejia & Christoph A. Thaiss & Sophie Joly & David G. Gonzalez & Lan Xu & Laure, 2012. "NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells," Nature, Nature, vol. 484(7395), pages 510-513, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature11012
    DOI: 10.1038/nature11012
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