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An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

Author

Listed:
  • Reto Gassmann

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego)

  • Andreas Rechtsteiner

    (University of California Santa Cruz)

  • Karen W. Yuen

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
    Present addresses: School of Biological Sciences, the University of Hong Kong, Pokfulam, Hong Kong (K.W.Y.); Department of Craniofacial Biology, University of Colorado, Health Sciences Center, Aurora, Colorado 80045, USA (F.B.); Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec H3C 3J7, Canada (P.M.); The Salk Institute for Biological Studies, San Diego, California 92186, USA (A.E.); Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA (J.M.).)

  • Andrew Muroyama

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego)

  • Thea Egelhofer

    (University of California Santa Cruz)

  • Laura Gaydos

    (University of California Santa Cruz)

  • Francie Barron

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
    Present addresses: School of Biological Sciences, the University of Hong Kong, Pokfulam, Hong Kong (K.W.Y.); Department of Craniofacial Biology, University of Colorado, Health Sciences Center, Aurora, Colorado 80045, USA (F.B.); Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec H3C 3J7, Canada (P.M.); The Salk Institute for Biological Studies, San Diego, California 92186, USA (A.E.); Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA (J.M.).)

  • Paul Maddox

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
    Present addresses: School of Biological Sciences, the University of Hong Kong, Pokfulam, Hong Kong (K.W.Y.); Department of Craniofacial Biology, University of Colorado, Health Sciences Center, Aurora, Colorado 80045, USA (F.B.); Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec H3C 3J7, Canada (P.M.); The Salk Institute for Biological Studies, San Diego, California 92186, USA (A.E.); Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA (J.M.).)

  • Anthony Essex

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
    Present addresses: School of Biological Sciences, the University of Hong Kong, Pokfulam, Hong Kong (K.W.Y.); Department of Craniofacial Biology, University of Colorado, Health Sciences Center, Aurora, Colorado 80045, USA (F.B.); Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec H3C 3J7, Canada (P.M.); The Salk Institute for Biological Studies, San Diego, California 92186, USA (A.E.); Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA (J.M.).)

  • Joost Monen

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
    Present addresses: School of Biological Sciences, the University of Hong Kong, Pokfulam, Hong Kong (K.W.Y.); Department of Craniofacial Biology, University of Colorado, Health Sciences Center, Aurora, Colorado 80045, USA (F.B.); Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec H3C 3J7, Canada (P.M.); The Salk Institute for Biological Studies, San Diego, California 92186, USA (A.E.); Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA (J.M.).)

  • Sevinc Ercan

    (Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill)

  • Jason D. Lieb

    (Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill)

  • Karen Oegema

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego)

  • Susan Strome

    (University of California Santa Cruz)

  • Arshad Desai

    (Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego)

Abstract

Centromere identity is thought to be epigenetically propagated by stable inheritance of nucleosomes containing the histone variant CENP-A; the authors propose a different model here in which germline transcription defines the genomic regions that exclude CENP-A incorporation during embryogenesis in the holocentric worm Caenorhabditis elegans.

Suggested Citation

  • Reto Gassmann & Andreas Rechtsteiner & Karen W. Yuen & Andrew Muroyama & Thea Egelhofer & Laura Gaydos & Francie Barron & Paul Maddox & Anthony Essex & Joost Monen & Sevinc Ercan & Jason D. Lieb & Kar, 2012. "An inverse relationship to germline transcription defines centromeric chromatin in C. elegans," Nature, Nature, vol. 484(7395), pages 534-537, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10973
    DOI: 10.1038/nature10973
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