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Deregulated MYC expression induces dependence upon AMPK-related kinase 5

Author

Listed:
  • Lidan Liu

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Jannes Ulbrich

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Judith Müller

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Torsten Wüstefeld

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Hepatology and Endocrinology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany)

  • Lukas Aeberhard

    (Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Theresia R. Kress

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Nathiya Muthalagu

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Lukas Rycak

    (Institute of Molecular Biology and Tumor Research, Emil-Mannkopff-Str. 2, 35037 Marburg, Germany)

  • Ramona Rudalska

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany)

  • Roland Moll

    (Institute for Pathology, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany)

  • Stefan Kempa

    (Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany)

  • Lars Zender

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Hepatology and Endocrinology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany)

  • Martin Eilers

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Daniel J. Murphy

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

Abstract

Oncogenic levels of MYC, the deregulation of which is implicated in many human tumours, are shown to establish a dependence on ARK5, offering insights into potential therapeutic strategies.

Suggested Citation

  • Lidan Liu & Jannes Ulbrich & Judith Müller & Torsten Wüstefeld & Lukas Aeberhard & Theresia R. Kress & Nathiya Muthalagu & Lukas Rycak & Ramona Rudalska & Roland Moll & Stefan Kempa & Lars Zender & Ma, 2012. "Deregulated MYC expression induces dependence upon AMPK-related kinase 5," Nature, Nature, vol. 483(7391), pages 608-612, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10927
    DOI: 10.1038/nature10927
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    Cited by:

    1. Marine Lanfranchi & Sozerko Yandiev & Géraldine Meyer-Dilhet & Salma Ellouze & Martijn Kerkhofs & Raphael Dos Reis & Audrey Garcia & Camille Blondet & Alizée Amar & Anita Kneppers & Hélène Polvèche & , 2024. "The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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