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The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

Author

Listed:
  • Takahito Sanada

    (International Research Center for Infectious Diseases, University of Tokyo, Minato-ku)

  • Minsoo Kim

    (International Research Center for Infectious Diseases, University of Tokyo, Minato-ku)

  • Hitomi Mimuro

    (International Research Center for Infectious Diseases, University of Tokyo, Minato-ku)

  • Masato Suzuki

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Michinaga Ogawa

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Akiho Oyama

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Hiroshi Ashida

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Taira Kobayashi

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Tomohiro Koyama

    (Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan)

  • Shinya Nagai

    (Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan)

  • Yuri Shibata

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Jin Gohda

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Jun-ichiro Inoue

    (Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Tsunehiro Mizushima

    (Picobiology Institute, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori, Akoh, Hyogo 678-1297, Japan)

  • Chihiro Sasakawa

    (International Research Center for Infectious Diseases, University of Tokyo, Minato-ku
    Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan)

Abstract

Shigella flexneri translocates several virulence factors into host cells during infection; one of these proteins, OspI, is a glutamine deamidase that specifically modifies UBC13, a protein involved in immune signalling.

Suggested Citation

  • Takahito Sanada & Minsoo Kim & Hitomi Mimuro & Masato Suzuki & Michinaga Ogawa & Akiho Oyama & Hiroshi Ashida & Taira Kobayashi & Tomohiro Koyama & Shinya Nagai & Yuri Shibata & Jin Gohda & Jun-ichiro, 2012. "The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response," Nature, Nature, vol. 483(7391), pages 623-626, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10894
    DOI: 10.1038/nature10894
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