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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Author

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  • Anirudh Prahallad

    (Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Chong Sun

    (Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Sidong Huang

    (Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Federica Di Nicolantonio

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino, Medical School, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy
    FIRC-IFOM Institute for Molecular Oncology, Via Adamello 16, 20100 Milan, Italy)

  • Ramon Salazar

    (IDIBELL, Institut Català d’Oncologia L’Hospitalet de Llobregat, Gran Via s/n, km 2, 7 08907 L’Hospitalet-Barcelona, Spain)

  • Davide Zecchin

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino, Medical School, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy)

  • Roderick L. Beijersbergen

    (Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Alberto Bardelli

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino, Medical School, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy
    FIRC-IFOM Institute for Molecular Oncology, Via Adamello 16, 20100 Milan, Italy)

  • René Bernards

    (Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

Abstract

Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal growth factor receptor (EGFR) in response to BRAF inhibition.

Suggested Citation

  • Anirudh Prahallad & Chong Sun & Sidong Huang & Federica Di Nicolantonio & Ramon Salazar & Davide Zecchin & Roderick L. Beijersbergen & Alberto Bardelli & René Bernards, 2012. "Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR," Nature, Nature, vol. 483(7387), pages 100-103, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10868
    DOI: 10.1038/nature10868
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    Cited by:

    1. Francesca Menghi & Edison T. Liu, 2022. "Functional genomics of complex cancer genomes," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    2. Ke Gong & Gao Guo & Nicole A. Beckley & Xiaoyao Yang & Yue Zhang & David E. Gerber & John D. Minna & Sandeep Burma & Dawen Zhao & Esra A. Akbay & Amyn A. Habib, 2021. "Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Mathurin Dorel & Bertram Klinger & Tommaso Mari & Joern Toedling & Eric Blanc & Clemens Messerschmidt & Michal Nadler-Holly & Matthias Ziehm & Anja Sieber & Falk Hertwig & Dieter Beule & Angelika Egge, 2021. "Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-26, November.
    4. Jin Jin & Qianying Liu & Wei Zheng & Zhenming Shun & Tun Tun Lin & Lei Gao & Yingwen Dong, 2020. "A Bayesian Method for the Detection of Proof of Concept in Early Phase Oncology Studies with a Basket Design," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(2), pages 167-179, July.
    5. Gholamreza Safaee Ardekani & Seyed Mehdi Jafarnejad & Larry Tan & Ardavan Saeedi & Gang Li, 2012. "The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-10, October.

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