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Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Author

Listed:
  • Darwin Jeyaraj

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
    Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Saptarsi M. Haldar

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Xiaoping Wan

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Mark D. McCauley

    (Baylor College of Medicine)

  • Jürgen A. Ripperger

    (University of Fribourg, CH-1700 Fribourg, Switzerland)

  • Kun Hu

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Yuan Lu

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Betty L. Eapen

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Nikunj Sharma

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Eckhard Ficker

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Michael J. Cutler

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • James Gulick

    (Cincinnati Children’s Hospital Medical Center)

  • Atsushi Sanbe

    (Cincinnati Children’s Hospital Medical Center)

  • Jeffrey Robbins

    (Cincinnati Children’s Hospital Medical Center)

  • Sophie Demolombe

    (Institut de Pharmacologie Moléculaire et Cellulaire, UMR CNRS 6097, Université de Nice Sophia Antipolis)

  • Roman V. Kondratov

    (Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University)

  • Steven A. Shea

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Urs Albrecht

    (University of Fribourg, CH-1700 Fribourg, Switzerland)

  • Xander H. T. Wehrens

    (Baylor College of Medicine)

  • David S. Rosenbaum

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Mukesh K. Jain

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

Abstract

Circadian rhythmicity of cardiac ion-channel expression and of an index of myocardial repolarization is under the control of Klf15, a clock-dependent oscillator that is required for generating transient outward potassium current, and deficiencies or excesses of which cause loss of rhythmic variation in myocardial and abnormal repolarization, and an enhanced susceptibility to ventricular arrhythmias.

Suggested Citation

  • Darwin Jeyaraj & Saptarsi M. Haldar & Xiaoping Wan & Mark D. McCauley & Jürgen A. Ripperger & Kun Hu & Yuan Lu & Betty L. Eapen & Nikunj Sharma & Eckhard Ficker & Michael J. Cutler & James Gulick & At, 2012. "Circadian rhythms govern cardiac repolarization and arrhythmogenesis," Nature, Nature, vol. 483(7387), pages 96-99, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10852
    DOI: 10.1038/nature10852
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    Cited by:

    1. Carlos Sánchez & Alfonso Bueno-Orovio & Erich Wettwer & Simone Loose & Jana Simon & Ursula Ravens & Esther Pueyo & Blanca Rodriguez, 2014. "Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-14, August.
    2. John Walmsley & Jose F Rodriguez & Gary R Mirams & Kevin Burrage & Igor R Efimov & Blanca Rodriguez, 2013. "mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-11, February.
    3. Nor Amira Syahira Mohd Azmi & Norsham Juliana & Sahar Azmani & Nadia Mohd Effendy & Izuddin Fahmy Abu & Nur Islami Mohd Fahmi Teng & Srijit Das, 2021. "Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    4. Feng Gao & Tian Liang & Yao Wei Lu & Xuyang Fu & Xiaoxuan Dong & Linbin Pu & Tingting Hong & Yuxia Zhou & Yu Zhang & Ning Liu & Feng Zhang & Jianming Liu & Andrea P. Malizia & Hong Yu & Wei Zhu & Doug, 2023. "A defect in mitochondrial protein translation influences mitonuclear communication in the heart," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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