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Opposite effects of fear conditioning and extinction on dendritic spine remodelling

Author

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  • Cora Sau Wan Lai

    (Molecular Neurobiology Program, Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA)

  • Thomas F. Franke

    (New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Wen-Biao Gan

    (Molecular Neurobiology Program, Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA)

Abstract

In mouse frontal cortex, fear conditioning and extinction cause dendritic spine elimination and, respectively, formation to occur on the same dendritic branches in a cue- and location-specific manner.

Suggested Citation

  • Cora Sau Wan Lai & Thomas F. Franke & Wen-Biao Gan, 2012. "Opposite effects of fear conditioning and extinction on dendritic spine remodelling," Nature, Nature, vol. 483(7387), pages 87-91, March.
  • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10792
    DOI: 10.1038/nature10792
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    Cited by:

    1. Lun Wang & Min Gao & Qinglong Wang & Liyuan Sun & Muhammad Younus & Sixing Ma & Can Liu & Li Shi & Yang Lu & Bo Zhou & Suhua Sun & Guoqing Chen & Jie Li & Quanfeng Zhang & Feipeng Zhu & Changhe Wang &, 2023. "Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Zhiwei Xu & Erez Geron & Luis M. PĂ©rez-Cuesta & Yang Bai & Wen-Biao Gan, 2023. "Generalized extinction of fear memory depends on co-allocation of synaptic plasticity in dendrites," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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