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Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

Author

Listed:
  • Paul Krimpenfort

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Ji-Ying Song

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Natalie Proost

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • John Zevenhoven

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Jos Jonkers

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Anton Berns

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    The Amsterdam Medical Center (AMC). The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

Abstract

In a mouse model of mammary carcinoma, loss of deleted in colorectal cancer (DCC) promotes metastasis formation, and in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, supporting the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.

Suggested Citation

  • Paul Krimpenfort & Ji-Ying Song & Natalie Proost & John Zevenhoven & Jos Jonkers & Anton Berns, 2012. "Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours," Nature, Nature, vol. 482(7386), pages 538-541, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10790
    DOI: 10.1038/nature10790
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