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Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

Author

Listed:
  • Teresa L. M. Thurston

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Michal P. Wandel

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Natalia von Muhlinen

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Ágnes Foeglein

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Felix Randow

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

Galectin 8, a cytosolic lectin, is shown to function as a danger receptor that detects damaged vesicles and protects cells from bacterial infection by inducing autophagy.

Suggested Citation

  • Teresa L. M. Thurston & Michal P. Wandel & Natalia von Muhlinen & Ágnes Foeglein & Felix Randow, 2012. "Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion," Nature, Nature, vol. 482(7385), pages 414-418, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7385:d:10.1038_nature10744
    DOI: 10.1038/nature10744
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