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Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

Author

Listed:
  • Guangbo Chen

    (Stowers Institute for Medical Research, 1000 East 50th Street
    University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA)

  • William D. Bradford

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Chris W. Seidel

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Rong Li

    (Stowers Institute for Medical Research, 1000 East 50th Street
    University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA)

Abstract

Aneuploidy is shown to be induced by pleiotropic stress conditions (especially Hsp90 inhbition) in yeast, leading to stress adaptation.

Suggested Citation

  • Guangbo Chen & William D. Bradford & Chris W. Seidel & Rong Li, 2012. "Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy," Nature, Nature, vol. 482(7384), pages 246-250, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10795
    DOI: 10.1038/nature10795
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