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Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

Author

Listed:
  • Stefanie Jäger

    (University of California-San Francisco
    California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA)

  • Dong Young Kim

    (University of California)

  • Judd F. Hultquist

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • Keisuke Shindo

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • Rebecca S. LaRue

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • Eunju Kwon

    (University of California)

  • Ming Li

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • Brett D. Anderson

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • Linda Yen

    (University of California)

  • David Stanley

    (University of California)

  • Cathal Mahon

    (University of California-San Francisco
    California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California)

  • Joshua Kane

    (University of California-San Francisco
    California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA)

  • Kathy Franks-Skiba

    (University of California-San Francisco
    California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA)

  • Peter Cimermancic

    (California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California)

  • Alma Burlingame

    (California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California)

  • Andrej Sali

    (California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California
    University of California
    HPC (Host Pathogen Circuitry) Group, University of California-San Francisco)

  • Charles S. Craik

    (California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California)

  • Reuben S. Harris

    (Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota)

  • John D. Gross

    (California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    University of California
    HPC (Host Pathogen Circuitry) Group, University of California-San Francisco)

  • Nevan J. Krogan

    (University of California-San Francisco
    California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
    HPC (Host Pathogen Circuitry) Group, University of California-San Francisco
    J. David Gladstone Institutes)

Abstract

The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection.

Suggested Citation

  • Stefanie Jäger & Dong Young Kim & Judd F. Hultquist & Keisuke Shindo & Rebecca S. LaRue & Eunju Kwon & Ming Li & Brett D. Anderson & Linda Yen & David Stanley & Cathal Mahon & Joshua Kane & Kathy Fran, 2012. "Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection," Nature, Nature, vol. 481(7381), pages 371-375, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10693
    DOI: 10.1038/nature10693
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