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Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

Author

Listed:
  • Jörg H. Fritz

    (University of Toronto
    Present addresses: Complex Traits Group, Department of Microbiology and Immunology, McGill University, Montreal H3G 0B1, Canada (J.H.F.); University of Bern, Institute of Infectious Disease, Friedbühlstrasse 51, 3010 Bern, Switzerland (S.H.); Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John’s A1B 3V6, Canada (M.L.).)

  • Olga Lucia Rojas

    (University of Toronto)

  • Nathalie Simard

    (University of Toronto
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network)

  • Douglas D. McCarthy

    (University of Toronto)

  • Siegfried Hapfelmeier

    (University of Bern
    Present addresses: Complex Traits Group, Department of Microbiology and Immunology, McGill University, Montreal H3G 0B1, Canada (J.H.F.); University of Bern, Institute of Infectious Disease, Friedbühlstrasse 51, 3010 Bern, Switzerland (S.H.); Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John’s A1B 3V6, Canada (M.L.).)

  • Stephen Rubino

    (University of Toronto)

  • Susan J. Robertson

    (University of Toronto)

  • Mani Larijani

    (University of Toronto
    Present addresses: Complex Traits Group, Department of Microbiology and Immunology, McGill University, Montreal H3G 0B1, Canada (J.H.F.); University of Bern, Institute of Infectious Disease, Friedbühlstrasse 51, 3010 Bern, Switzerland (S.H.); Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John’s A1B 3V6, Canada (M.L.).)

  • Jean Gosselin

    (University of Laval)

  • Ivaylo I. Ivanov

    (Columbia University Medical Center, College of Physicians and Surgeons)

  • Alberto Martin

    (University of Toronto)

  • Rafael Casellas

    (Genomics and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health)

  • Dana J. Philpott

    (University of Toronto)

  • Stephen E. Girardin

    (University of Toronto)

  • Kathy D. McCoy

    (University of Bern)

  • Andrew J. Macpherson

    (University of Bern)

  • Christopher J. Paige

    (University of Toronto
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network)

  • Jennifer L. Gommerman

    (University of Toronto)

Abstract

IgA secreting plasma cells in the lamina propria are shown to be an important source of iNOS and TNF required to maintain the homeostatic balance between intestinal microbes and the immune system.

Suggested Citation

  • Jörg H. Fritz & Olga Lucia Rojas & Nathalie Simard & Douglas D. McCarthy & Siegfried Hapfelmeier & Stephen Rubino & Susan J. Robertson & Mani Larijani & Jean Gosselin & Ivaylo I. Ivanov & Alberto Mart, 2012. "Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut," Nature, Nature, vol. 481(7380), pages 199-203, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7380:d:10.1038_nature10698
    DOI: 10.1038/nature10698
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