IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7376d10.1038_nature10577.html
   My bibliography  Save this article

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

Author

Listed:
  • Nicolas L. Fawzi

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Jinfa Ying

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Rodolfo Ghirlando

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Dennis A. Torchia

    (National Institute of Dental and Craniofacial Research, National Institutes of Health)

  • G. Marius Clore

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

Abstract

Visibility cloak for hidden proteins When proteins associate with larger structures such as polymers, membranes or solid supports, they usually become 'invisible' to the techniques used to visualize them as free molecules in solution. Marius Clore and colleagues have now developed a new technique of solution nuclear magnetic resonance that can probe such exchange phenomena at atomic resolution. Termed dark-state exchange saturation transfer (DEST), the procedure is demonstrated here by following the aggregation of the amyloid-β monomers implicated in Alzheimer's disease. It should also be adaptable to many of the supramolecular systems encountered in biological systems and materials science.

Suggested Citation

  • Nicolas L. Fawzi & Jinfa Ying & Rodolfo Ghirlando & Dennis A. Torchia & G. Marius Clore, 2011. "Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR," Nature, Nature, vol. 480(7376), pages 268-272, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10577
    DOI: 10.1038/nature10577
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10577
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10577?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10577. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.