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Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Author

Listed:
  • Julian P. Vivian

    (School of Biomedical Sciences, Monash University)

  • Renee C. Duncan

    (School of Biomedical Sciences, Monash University)

  • Richard Berry

    (School of Biomedical Sciences, Monash University)

  • Geraldine M. O’Connor

    (Cancer and Inflammation Program, National Cancer Institute-Frederick)

  • Hugh H. Reid

    (School of Biomedical Sciences, Monash University)

  • Travis Beddoe

    (School of Biomedical Sciences, Monash University)

  • Stephanie Gras

    (School of Biomedical Sciences, Monash University)

  • Philippa M. Saunders

    (University of Melbourne)

  • Maya A. Olshina

    (School of Biomedical Sciences, Monash University)

  • Jacqueline M. L. Widjaja

    (University of Melbourne)

  • Christopher M. Harpur

    (University of Melbourne)

  • Jie Lin

    (University of Melbourne)

  • Sebastien M. Maloveste

    (Non-Human Primate Immunogenetics and Cellular Immunology Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • David A. Price

    (Immunity and Biochemistry, Cardiff University School of Medicine, Heath Park
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Bernard A. P. Lafont

    (Non-Human Primate Immunogenetics and Cellular Immunology Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Daniel W. McVicar

    (Cancer and Inflammation Program, National Cancer Institute-Frederick)

  • Craig S. Clements

    (School of Biomedical Sciences, Monash University)

  • Andrew G. Brooks

    (University of Melbourne)

  • Jamie Rossjohn

    (School of Biomedical Sciences, Monash University
    Immunity and Biochemistry, Cardiff University School of Medicine, Heath Park)

Abstract

HLA recognition by a killer receptor The interaction between the three-domain killer immunoglobulin receptor (KIR3D) and human leukocyte antigen (HLA) class I molecules is central to the regulation of natural killer cell activity, as well as being key to the control of HIV replication and some haematological malignancies. The crystal structure of a complex between a KIR3D and a self-peptide bearing HLA-B57 molecule has now been determined. The structure shows why the KIR3D family is specific for the HLA-B locus, whereas KIR2D receptors are restricted to HLA-C.

Suggested Citation

  • Julian P. Vivian & Renee C. Duncan & Richard Berry & Geraldine M. O’Connor & Hugh H. Reid & Travis Beddoe & Stephanie Gras & Philippa M. Saunders & Maya A. Olshina & Jacqueline M. L. Widjaja & Christo, 2011. "Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B," Nature, Nature, vol. 479(7373), pages 401-405, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7373:d:10.1038_nature10517
    DOI: 10.1038/nature10517
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