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Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Author

Listed:
  • Jie Liu

    (University of California, Davis)

  • Ludovic Renault

    (University of California, Davis)

  • Xavier Veaute

    (CEA-DSV-Institut de Radiobiologie Cellulaire et Moléculaire, UMR217 CNRS/CEA)

  • Francis Fabre

    (CEA-DSV-Institut de Radiobiologie Cellulaire et Moléculaire, UMR217 CNRS/CEA)

  • Henning Stahlberg

    (University of California, Davis
    Center for Cellular Imaging and Nanoanalytics, University Basel)

  • Wolf-Dietrich Heyer

    (University of California, Davis
    University of California, Davis)

Abstract

Rad51 and DNA repair DNA strand exchange, a process that helps to maintain the integrity of the genome, is promoted in eukaryotes by the Rad51 protein. Eukaryotes also have homologues of Rad51 with functions that are less well defined. Wolf-Dietrich Heyer and colleagues show that in yeast, two of these proteins, Rad55 and Rad57, form a complex that promotes recombination by stabilizing the Rad51 filament against the anti-recombinogenic activity of a helicase, Srs2. These results suggest that the Rad51 filament is a reversible intermediate, the stability of which reflects competing actions of other proteins. This mechanism may have relevance for the human RAD51 paralogues that have important roles in tumour suppression and disease.

Suggested Citation

  • Jie Liu & Ludovic Renault & Xavier Veaute & Francis Fabre & Henning Stahlberg & Wolf-Dietrich Heyer, 2011. "Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation," Nature, Nature, vol. 479(7372), pages 245-248, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7372:d:10.1038_nature10522
    DOI: 10.1038/nature10522
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