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The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre

Author

Listed:
  • Johannes Fritsch

    (Mikrobiologie, Institut für Biologie, Humboldt-Universität zu Berlin, Chausseestraße 117)

  • Patrick Scheerer

    (Institut für Medizinische Physik und Biophysik (CC2), Charité–Universitätsmedizin Berlin, Charitéplatz 1)

  • Stefan Frielingsdorf

    (Mikrobiologie, Institut für Biologie, Humboldt-Universität zu Berlin, Chausseestraße 117)

  • Sebastian Kroschinsky

    (Institut für Medizinische Physik und Biophysik (CC2), Charité–Universitätsmedizin Berlin, Charitéplatz 1)

  • Bärbel Friedrich

    (Mikrobiologie, Institut für Biologie, Humboldt-Universität zu Berlin, Chausseestraße 117)

  • Oliver Lenz

    (Mikrobiologie, Institut für Biologie, Humboldt-Universität zu Berlin, Chausseestraße 117)

  • Christian M. T. Spahn

    (Institut für Medizinische Physik und Biophysik (CC2), Charité–Universitätsmedizin Berlin, Charitéplatz 1
    Zentrum für Biophysik und Bioinformatik, Humboldt-Universität zu Berlin, Invalidenstraße 42)

Abstract

Oxygen-tolerant hydrogenases Hydrogenases are metalloprotein enzymes that catalyse the reversible oxidation of dihydrogen to protons and electrons, a critical pathway in anaerobic metabolism. This reaction is of particular interest for hydrogen-based applications, in fuel cells for instance, but many applications are hindered by the high oxygen sensitivity that is an intrinsic feature of most hydrogenases. Two groups report the structures of oxygen-tolerant hydrogenases, one from the soil bacterium Ralstonia eutropha and the other from the marine bacterium Hydrogenovibrio marinus. The structures shed light on how redox-sensitive active-site intermediates are protected from destruction. Both enzymes feature a novel iron-sulphur centre at the active site, coordinated by a group of cysteine residues.

Suggested Citation

  • Johannes Fritsch & Patrick Scheerer & Stefan Frielingsdorf & Sebastian Kroschinsky & Bärbel Friedrich & Oliver Lenz & Christian M. T. Spahn, 2011. "The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre," Nature, Nature, vol. 479(7372), pages 249-252, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7372:d:10.1038_nature10505
    DOI: 10.1038/nature10505
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